首页 > 论文 > 中国激光 > 44卷 > 4期(pp:407001--1)

离体生物组织激光焊接特性实验研究

Laser Welding Characteristics of Biological Tissues in vitro

  • 摘要
  • 论文信息
  • 参考文献
  • 被引情况
  • PDF全文
分享:

摘要

为了获得激光焊接工艺参数对离体生物组织融合效果的影响规律, 设计实验探究了激光功率、激光扫描方式等参数对离体皮肤切口融合形貌及抗张强度的影响, 并对工艺参数进行了优化。结果表明, 采用小功率长时间工艺规范焊接离体皮肤组织, 组织切口融合效果较好、抗张强度较高, 并且可以减小不可逆的热损伤; 采用分段扫描焊接方式, 可以加强切口附近成分的活性, 减小切口热损伤。在此基础上, 采用优化的工艺参数进行可靠性实验, 并对切口抗张强度进行了测试。结果表明, 在该工艺条件下, 组织切口可实现全层融合, 并且无烧损、碳化等缺陷, 与连续激光焊接工艺相比, 焊接时间可减少30%~40%, 焊后组织切口抗张强度可达0.38 MPa, 满足强度要求。

Abstract

To find out the role of laser parameters on in-vitro tissue bonding, experiments are designed to study the effect of laser parameters, such as power and scanning mode, on the appearance and tensile strength of in-vitro skin tissue incision, and then the process parameters are optimized. Results show that the appearance and tensile strength of tissue incision is better and greater when we use low laser power with long welding time, and also the irreversible thermal damage decreases. Using interval laser scanning increases the bioactivity closed to the incision and decreases the thermal damage. Experiments are performed to verify the reliability and stability of the optimized parameters, and the tensile strength of incision is tested. Results show that the bonding along the depth of tissue can be realized and no carbide or burning occurs. Compared with that of the continuous laser welding process, the welding time is decreased by 30%-40%, and the tensile strength of incision is 0.38 MPa, which can meet the requirement.

投稿润色
补充资料

中图分类号:TN249

DOI:10.3788/cjl201744.0407001

所属栏目:生物医学光子学与激光医学

基金项目:中央高校基本科研业务费专项资金(AE16001)

收稿日期:2016-11-08

修改稿日期:2016-12-08

网络出版日期:--

作者单位    点击查看

黄俊:南京理工大学材料科学与工程学院, 江苏 南京 210094
李聪:南京理工大学材料科学与工程学院, 江苏 南京 210094
王克鸿:南京理工大学材料科学与工程学院, 江苏 南京 210094
李乐乐:南京理工大学材料科学与工程学院, 江苏 南京 210094

联系人作者:黄俊(huangjun0061@126.com)

备注:黄俊(1978-), 女, 博士, 讲师, 硕士生导师, 主要从事焊接过程数值模拟、激光生物组织焊接等方面的研究。

【1】Nourbakhsh M S, Khosroshahi M E. An in-vitro investigation of skin tissue soldering using gold nanoshells and diode laser[J]. Lasers in Medical Science, 2011, 26(1): 49-55.

【2】Wang S, Zhao J, Lui H, et al. Monte Carlo simulation of near infrared autofluorescence measurements of in vivo skin[J]. Journal of Photochemistry & Photobiology B, 2011, 105(3): 183-189.

【3】Pan Zhenhua, Li Yingxin, Wang Xing, et al. Effects of low-level laser therapy on cutaneous wound healings with three doses[J]. Chinese J Lasers, 2010, 37(2): 599-604.
潘振华, 李迎新, 王 兴, 等. 3种剂量弱激光对大鼠皮肤创伤愈合的影响[J]. 中国激光, 2010, 37(2): 599-604.

【4】Hu Liming, Liu Yun, Lu Zhihua, et al. Skin welding with a combination of 980 nm and 1064 nm lasers[J]. Chinese J Lasers, 2011, 38(4): 0404001.
胡黎明, 刘 云, 芦志华, 等. 将980 nm/1064 nm双波长半导体激光皮肤焊接[J]. 中国激光, 2011, 38(4): 0404001.

【5】Dadpay M, Sharifian Z, Bayat M, et al. Effects of pulsed infrared low level-laser irradiation on open skin wound healing of healthy and streptozotocin-induced diabetic rats by biomechanical evaluation[J]. Journal of Photochemistry & Photobiology B, 2012, 111(11): 1-8.

【6】Alfano R R, Sriramoju V. Method for pocosecond and femtosecond laser tissue welding: US8974444B2[P]. 2015-03-10.

【7】Babak N, Thomas E, Murphy, et al. Simulation of laser propagation through a three-layer human skin model in the spectral range from 1000 to 1900 nm[J]. Journal of Biomedical Optics, 2014, 19(7): 075003.

【8】Guan K W, Jiang Y Q, Sun C S, et al. A two-layer model of laser interaction with skin: A photothermal effect analysis[J]. Optics & Laser Technology, 2011, 43(3): 425-429.

【9】Rebecca V, Noojin G D, Harbert C A, et al. Porcine skin damage thresholds for 0.6 to 9.5 cm beam diameters from 1070-nm continuous-wave infrared laser radiation[J]. Journal of Biomedical Optics, 2014, 19(3): 35007-35009.

【10】Rossi F, Matteini P, Esposito G, et al. In vivo experimental study on laser welded ICG-loaded chitosan patches for vessel repair[C]. SPIE, 2011, 7883: 78833M.

【11】Tabakogˇlu H O, Topalogu N M. The effect of irradiance level in 980-nm diode laser skin welding[J]. Photomedicine & Laser Surgery, 2010, 28(4): 453-458.

【12】Halder R H, Katz A, Savage H, et al. Laser skin welding using water absorption and heat management[C]. SPIE, 2005, 5686: 253-255.

【13】Lu Tianjian, Xu Feng. Mechanical properties of skin: A review[J]. Advances in Mechanics, 2008, 38(4): 393-426.
卢天健, 徐 峰. 皮肤的力学性能概述[J]. 力学进展, 2008, 38(4): 393-426.

引用该论文

Huang Jun,Li Cong,Wang Kehong,Li Lele. Laser Welding Characteristics of Biological Tissues in vitro[J]. Chinese Journal of Lasers, 2017, 44(4): 0407001

黄俊,李聪,王克鸿,李乐乐. 离体生物组织激光焊接特性实验研究[J]. 中国激光, 2017, 44(4): 0407001

您的浏览器不支持PDF插件,请使用最新的(Chrome/Fire Fox等)浏览器.或者您还可以点击此处下载该论文PDF