中国激光, 2017, 44 (8): 0807001, 网络出版: 2017-09-13
生物组织的亚扩散散射及其光谱技术的应用 下载: 733次
Sub-Diffuse Scattering of Biological Tissues and Its Application to Spectroscopy
医用光学 漫反射模型 Monte Carlo模拟 高阶光学参量 亚扩散散射 单光纤反射探针 medical optics diffuse reflection model Monte Carlo simulation high-order optic parameter sub-diffuse scattering single-fiber reflectance probe
摘要
采用Monte Carlo模拟研究了单光纤反射探针的漫反射率, 发现小孔径探测器收集到的亚扩散光对散射相函数是敏感的, 而散射相函数与生物组织的微观结构有关。研究了一个适用于小孔径测量的半经验漫反射模型, 分析了与生物组织微观结构有关的二阶和三阶光学参量对该模型的影响。结果表明, 两个高阶光学参量对漫反射的影响具有相反的效果, 并且对于光学各向异性的生物组织, 这两种影响是不可忽略的。给出了一个简化的半经验模型及其适用条件, 这为生物组织散射特性及相关微观结构的在体测量提供了新的技术支持。
Abstract
The diffuse reflectance of single-fiber reflectance probe is studied with the Monte Carlo simulation, and we find that the sub-diffuse scattering light is sensitive to the scattering phase function (SPF) related to tissue microstructure. A semi-empirical diffuse reflection model for small aperture measurement is studied, and the influences of second-order and third-order optic parameters on this model are analyzed. It shows that the two parameters have contrary effects on diffuse reflectance, and both effects are non-negligible for optically anisotropic biological tissues. A simplified semi-empirical model and its application condition are given, which provides potentially applicable support for measurement of tissue scattering properties and associated microstructure.
刘迎, 罗雯倩, 王汝丹, 王兴. 生物组织的亚扩散散射及其光谱技术的应用[J]. 中国激光, 2017, 44(8): 0807001. Liu Ying, Luo Wenqian, Wang Rudan, Wang Xing. Sub-Diffuse Scattering of Biological Tissues and Its Application to Spectroscopy[J]. Chinese Journal of Lasers, 2017, 44(8): 0807001.