激光生物学报, 2017, 26 (4): 321, 网络出版: 2017-11-07  

窄等离子体吸收谱线宽度的纳米金锥用于光声成像

Gold Nanobipyramids with Narrow Plasmon Linewidths Dedicated to Photoacoustic Imaging
作者单位
华南师范大学激光生命科学研究所 激光生命科学教育部重点实验室, 生物光子学研究院, 广东 广州 510631
摘要
无损光声成像技术结合了纯光学成像高选择特性和纯超声成像中深穿透特性的优点, 克服了光散射限制, 实现了对活体深层组织的高分辨、高对比度成像。该成像技术对内源物质例如脱氧血红蛋白、含氧血红蛋白、黑色素、脂质等进行成像, 提供了活体生物组织结构和功能信息, 已经在生物医学领域表现出巨大的应用前景。然而, 很多与病理过程相关的特征分子的光吸收能力较弱, 在活体环境中难以被光声成像系统所识别, 从而限制了光声成像技术的应用范围。基于功能纳米探针的光声成像-光声分子成像极大拓展光声成像的应用范围, 可以在活体层面对病理过程进行分子水平的定性和定量研究, 将为实现目标疾病的早期诊断提供强大的技术支持。本文发展在近红外具有窄吸收线宽(半高宽仅为60 nm)的纳米金锥作为新型的光声探针。通过选择不同径长比的纳米金锥, 可以任意调节纳米金锥的吸收峰。通过调谐激光器的波长, 可实现对不同吸收峰纳米金锥的选择性激发。纳米金锥将有可能用于多光谱光声成像, 实现对不同靶标的目标分子探测。
Abstract
Photoacoustic imaging (PAI) overcomes the optical diffusion limit and provides deeper tissue imaging with high spatial resolution by integrating high selectivity of optical imaging with deep penetrating of ultrasonic imaging. Various endogenous chromophores such as oxygenated hemoglobin, deoxygenated hemoglobin, melanin, and lipid can serve as PAI contrast agents, enabling brain function study, tumor microcirculation visualization, and atherosclerotic plaque identification. PAI has shown great application prospect in biomedicine. However, in most cases, intrinsic biomarkers of many diseases cannot generate PA signals by themselves after laser excitation. Using exogenous PA probes to stain PAI-invisible biomarkers is effective at fully utilizing PAI’s potential at a depth and spatial resolution. The combination of the functional probes and PAI: photoacoustic molecular imaging, will expand the application range of PAI, ultimately accurately detects intrinsic biomarkers of these diseases in living subjects. Photoacoustic molecular imaging will provide strong technical support for the early diagnosis of target disease. In this work, we develop gold nanobipyramids with narrow plasmon linewidths as a novel photoacoustic probe. The absorption peak of the gold nanobipyramids can be adjusted arbitrarily by selecting different ratio of length and diameter. By tuning the wavelength of the excitation laser, photoacouatic signal of gold nanobipyramids with different absorption peaks can be excited selectively. The gold nanobipyramids with narrow plasmon linewidths is likely for the be used for multispectral photoacoustic imaging for the detection of different targets.

刘丽鸣, 覃欢. 窄等离子体吸收谱线宽度的纳米金锥用于光声成像[J]. 激光生物学报, 2017, 26(4): 321. LIU Li ming, QIN Huan. Gold Nanobipyramids with Narrow Plasmon Linewidths Dedicated to Photoacoustic Imaging[J]. Acta Laser Biology Sinica, 2017, 26(4): 321.

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