Chinese Optics Letters, 2017, 15 (12): 120602, Published Online: Jul. 18, 2018
Real-time measurement of nano-particle size using differential optical phase detection Download: 806次
Abstract
We demonstrate a size sensing technique for nano-particles using optical differential phase measurement by a dual fiber interferometer through phase-generated carrier (PGC) demodulation. Nano-particle diameters are obtained from the differential phase shift as a result of adding an optical scattering perturbation into two-beam interference. Polystyrene nano-particles with diameters from 200 to 900 nm in a microfluidic channel are detected using this technique to acquire real-time particle diameters. Compared with amplitude sensing with over 10 mW of laser irradiance, particle sizing by PGC phase sensing can be achieved at a laser power as low as 1.18 mW. We further analyze major sources of noise in order to improve the limits of detection. This sensing technique may find a broad range of applications from the real-time selection of biological cell samples to rare cell detection in blood samples for early cancer screening.
Qing Li, He Huang, Feng Lin, Xingkun Wu. Real-time measurement of nano-particle size using differential optical phase detection[J]. Chinese Optics Letters, 2017, 15(12): 120602.