Photonics Research, 2017, 5 (6): 06000728, Published Online: Dec. 7, 2017   

Intracavity biosensor based on the Nd:YAG waveguide laser: tumor cells and dextrose solutions Download: 534次

Author Affiliations
1 Department of Respiration, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, China
2 Department of Ophthalmology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, China
3 Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, China
4 School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China
5 Departamento Física Aplicada, Facultad Ciencias, Universidad de Salamanca, Salamanca 37008, Spain
Abstract
This work demonstrates the Nd:YAG waveguide laser as an efficient platform for the bio-sensing of dextrose solutions and tumor cells. The waveguide was fabricated in an Nd:YAG crystal with the cooperation of ultrafast laser writing and ion irradiation. The laser oscillation in the Nd:YAG waveguide is ultrasensitive to the external environment of the waveguide. Even a weak disturbance leads to a large variation of the output power of the laser. According to this feature, an Nd:YAG waveguide coated with graphene and WSe2 layers is used as substrate for the microfluidic channel. When the microflow crosses the Nd:YAG waveguide, the laser oscillation in the waveguide is disturbed and induces fluctuation of the output laser. According to the fluctuation, the microflow is detected with a sensitivity of 10 mW/RIU.

Guanhua Li, Huiyuan Li, Rumei Gong, Yang Tan, Javier Rodríguez Vázquez de Aldana, Yuping Sun, Feng Chen. Intracavity biosensor based on the Nd:YAG waveguide laser: tumor cells and dextrose solutions[J]. Photonics Research, 2017, 5(6): 06000728.

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