Optical microcavities have attracted tremendous interest in both fundamental and applied research in the past few decades, thanks to their small footprint, easy integrability, and high quality factors. Using total internal reflection from a dielectric interface or a photonic band gap in a periodic system, these photonic structures do not rely on conventional metal-coated mirrors to confine light in small volumes, which have brought forth new developments in both classical and quantum optics. This focus issue showcases several such developments and related findings, which may pave the way for the next generation of on-chip photonic devices based on microcavities.