中国激光, 2018, 45 (2): 0207008, 网络出版: 2018-02-28
肿瘤微环境响应的智能纳米载体在肿瘤光动力治疗中的应用 下载: 1627次特邀综述
Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers
生物光学 肿瘤微环境 刺激因子 光动力治疗 智能化纳米载体 biotechnology tumor-microenvironment stimulating factors photodynamic therapy smart nanocarrier
摘要
光动力治疗是基于微创的新型肿瘤治疗方法,利用光敏剂吸收外源可见-近红外光光能促使光敏剂与分子氧反应,产生高活性光化学产物——活性氧物质,诱导肿瘤细胞凋亡或坏死,具有低免疫原性、低成本、高选择性等特点,已成为癌症治疗基础研究与临床转化的新热点。然而,实体肿瘤内微环境因子导致的光动力治疗效果下降及肿瘤细胞耐受等问题,阻碍了光动力治疗的发展与临床医学应用。随着纳米技术与生物医学工程等交叉领域的快速发展,以及对肿瘤微环境的深入研究,利用肿瘤微环境因子设计的智能响应性纳米载体用于癌症的诊断与协同治疗近年来受到广泛关注。基于此,综述了肿瘤环境响应的智能化纳米载体系统在肿瘤光动力治疗中的最新研究进展,为肿瘤的光动力治疗提供参考与新的研究思路。
Abstract
Photodynamic therapy is a noninvasive therapy of cancers that utilizes exogenous visible, near-infrared light to induce the photosensitizer to react with molecular oxygen to produce a highly active photochemical product of reactive oxygen species which can induce apoptosis or necrosis of tumor cells, with low immunogenicity, low cost, high selectivity and other characteristics. Photodynamic therapy has become a hot topic in the basic research and clinical transformation of cancer treatment. However, the decreased effect of photodynamic therapy induced by tumor-microenvironment factors and the tolerance of tumor cells hinder the development of photodynamic therapy and clinical application. With the rapid development of comprehensive fields such as nanotechnology and biomedical engineering, and the deepening study of tumor microenvironment, the tumor-microenvironment activable smart nanocarrier system for the diagnosis and the synergistic treatment of cancer draw high attention in recent years. Based on this, the research of tumor-microenvironment activable smart nanocarrier system is reviewed to provide a reference and a new research idea for photodynamic therapy of tumors.
蓝善优, 张达, 刘小龙, 曾永毅. 肿瘤微环境响应的智能纳米载体在肿瘤光动力治疗中的应用[J]. 中国激光, 2018, 45(2): 0207008. Lan Shanyou, Zhang Da, Liu Xiaolong, Zeng Yongyi. Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers[J]. Chinese Journal of Lasers, 2018, 45(2): 0207008.