发光学报, 2018, 39 (3): 280, 网络出版: 2018-04-09
金纳米星/双锥的可控制备、光热转换及体外光热治疗
Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids
摘要
采用种子生长法,分别制备了金纳米星和金纳米双锥,利用透射电子显微镜、紫外-可见(UV-Vis)分光光度计等对样品进行了表征,并评价了金纳米星和金纳米双锥的光热转换性能、生物相容性以及体外光热治疗性能。结果表明,金纳米星和金纳米双锥的UV-Vis吸收峰位于808 nm和815 nm左右。在808 nm激光辐照下,光热转换效率分别为48.43%和53.68%。细胞实验表明,金纳米星和金纳米双锥具有良好的生物相容性。808 nm激光辐照5 min后,MCF-7细胞存活率分别降至22.54%和13.73%;且在同等条件下,金纳米双锥具有更加优异的光热治疗性能,是一种安全、高性能的肿瘤光热治疗用纳米探针材料。
Abstract
Using seed-growth method, gold nanostars and gold nanobipyramids were synthesized, respectively, and they were characterized by transmission electron microscope and ultraviolet-visible (UV-Vis) spectrophotometer. Moreover, the photothermal conversion, biocompatibility and in vitro photothermal therapy (PTT) of gold nanostars and gold nanobipyramids were evaluated. The results show that the UV-Vis absorption peaks of gold nanostars and gold nanobipyramids are located at about 808 nm and 815 nm, and the photothermal conversion efficiency is calculated to be 48.43% and 53.68%. The cell experiments indicate that the gold nanostars and gold nanobipyramids have good biocompatibility, and the viabilities of MCF-7 cells incubate with gold nanostars and gold nanobipyramids are decreased to be about 22.54% and 13.73%, after they are irradiated by 808 nm laser for 5 min, respectively. Furthermore, compared with the gold nanostars, the gold nanobipyramids have more excellent PTT performance, which could be good candidate as safe and high-efficient nanoprobe material for PTT in tumors.
吴頔, 樊淼, 张露云, 邢晶晶, 吕树芳, 曾乐勇. 金纳米星/双锥的可控制备、光热转换及体外光热治疗[J]. 发光学报, 2018, 39(3): 280. WU Di, FAN Miao, ZHANG Lu-yun, XING Jing-jing, LYU Shu-fang, ZENG Le-yong. Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids[J]. Chinese Journal of Luminescence, 2018, 39(3): 280.