光谱学与光谱分析, 2018, 38 (3): 727, 网络出版: 2018-04-09  

基于修正脉搏色素谱的循环血量检测方法

Determination of Circulation Blood Volume by Modified Pulse Dye Densitometry
作者单位
1 吉林大学仪器科学与电气工程学院, 吉林 长春 130061
2 吉林大学临床医学院, 吉林 长春 130021
摘要
循环血量(CBV)作为主要的血流动力学参数, 在心血管疾病的病情评估和手术监护中具有重要的临床应用价值。 将吲哚菁绿色素(ICG)作为示踪剂的脉搏色素谱法, 通过建立ICG稀释排泄的色素谱曲线, 实现CBV的在体无创测量。 在实际临床应用中, 由于受到血氧波动和环境背景光等干扰因素的影响, 脉搏色素谱法测量CBV的准确度低于预期值。 为解决这一问题, 研究了一种基于修正脉搏色素谱的循环血量检测方法。 具体操作是, 在患者的肘静脉处注入吲哚菁绿试剂, 利用光电传感器分别采集特征波长点的透射光谱信号和背景光电信号, 采用差分算法消除血氧波动和环境背景光的干扰影响, 建立准确的ICG色素谱曲线, 从而计算CBV等血流动力学参数。 与131I同位素“金标准法”相比较的试验结果表明, 该研究提出的基于修正脉搏色素谱的循环血量检测方法, 将CBV测量的平均相对误差从6.85%降低为4.53%, 显著提高了其测量准确度。
Abstract
Circulating blood volume (CBV) is important for disease evaluation and operation monitoring of patients with cardiovascular and cerebrovascular diseases in clinical application as the main hemodynamic parameters. Indocyanine green (ICG) was used as a tracer in the pulse dye densitometry, and we detected CBV noninvasively in vivo by establishing the spectral curve of the diluted excreted ICG. In clinical application, the accuracy of CBV detected with pulse dye densitometry is lower than the expected value owing to the influences of blood oxygen fluctuation and background light. To solve the problem, this paper researched circulation blood volume detection by modified pulse dye densitometry. The specific process was as follows. We injected the ICG reagent into the vein in the elbow of patient, and collected the transmission spectrum signal and the background photoelectric signal respectively using the photoelectric sensor. Then we conducted differential operation on the collected data to eliminate the influences of blood oxygen fluctuation and background light and established an accurate ICG spectral curve. So CBV and other hemodynamic parameters could be calculated finally. The result of the comparative test among 131I isotope method, the “gold standard”, and the proposed method indicated that the modified pulse dye densitometry reduced the average relative error of CBV detection from 6.85% to 4.53%, which improved the detection accuracy.

刘光达, 尚小虎, 魏星, 刘旸, 刘颂阳, 查雨彤. 基于修正脉搏色素谱的循环血量检测方法[J]. 光谱学与光谱分析, 2018, 38(3): 727. LIU Guang-da, SHANG Xiao-hu, WEI Xing, LIU Yang, LIU Song-yang, ZHA Yu-tong. Determination of Circulation Blood Volume by Modified Pulse Dye Densitometry[J]. Spectroscopy and Spectral Analysis, 2018, 38(3): 727.

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