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3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging

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Abstract

Photoacoustic (PA) microscopy comes with high potential for human skin imaging, since it allows noninvasively high-resolution imaging of the natural hemoglobin at depths of several millimeters. Here, we developed a PA microscopy to achieve high-resolution, high-contrast, and large field of view imaging of skin. A three-dimensional (3D) depth-coding technology was used to encode the depth information in PA images, which is very intuitive for identifying the depth of blood vessels in a two-dimensional image, and the vascular structure can be analyzed at different depths. Imaging results demonstrate that the 3D depth-coded PA microscopy should be translated from the bench to the bedside.

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DOI:10.3788/col201816.081701

所属栏目:Medical optics and biotechnology

基金项目:This work was supported by the National Natural Science Foundation of China (Nos. 11774101, 61627827, 81630046, and 91539127), the Science and Technology Planning Project of Guangdong Province, China (No. 2015B020233016), the Distinguished Young Teacher Project in Higher Education of Guangdong, China (No. YQ2015049), and the Science and Technology Youth Talent for Special Program of Guangdong, China (No. 2015TQ01X882).

收稿日期:2018-05-16

录用日期:2018-06-06

网络出版日期:2018-07-17

作者单位    点击查看

Zhongwen Cheng:MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, ChinaCollege of Biophotonics, South China Normal University, Guangzhou 510631, China
Haigang Ma:College of Biophotonics, South China Normal University, Guangzhou 510631, China
Zhiyang Wang:College of Biophotonics, South China Normal University, Guangzhou 510631, China
Sihua Yang:MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, ChinaCollege of Biophotonics, South China Normal University, Guangzhou 510631, China

联系人作者:Sihua Yang(yangsh@scnu.edu.cn)

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引用该论文

Zhongwen Cheng, Haigang Ma, Zhiyang Wang, Sihua Yang, "3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging," Chinese Optics Letters 16(8), 081701 (2018)

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