孤儿核受体亚家族6成员1(nuclear receptor subfamily 6 group member1,Nr6a1)是激活配体转录因子的核受体超家族成员,也称为生殖细胞核因子(germ cell nuclear factor, GCNF)或视黄酸受体相关睾丸相关核受体(retinoic acid receptor-related testis-associated receptor,RTR)。作为转录因子,Nr6a1通过与靶基因启动子区的DR0元件(TCAAGGTCA)结合发挥转录抑制作用。Nr6a1主要高表达于成熟的生殖细胞、分化阶段的胚胎干细胞以及畸胎瘤等生殖细胞肿瘤中,具有一定的时空表达特异性和组织表达特异性。目前已鉴定了一批Nr6a1的上、下游调控分子,包括miR-181a、let7、Oct4、PPARδ等,通过基因间的互作,Nr6a1在细胞分化、发育、代谢等生物学过程中发挥重要调节作用。

Nuclear receptor subfamily 6 group member1 (Nr6a1) is an active ligand transcription factor member of the nuclear receptor superfamily, also known as germ cell nuclear factor (GCNF) or retinoic acid receptor-related testis-associated receptor (RTR). As a transcription factor, Nr6a1 plays a role of transcriptional inhibition by binding to the DR0 element (TCAAGGTCA) in the target gene promoter region. Nr6a1 is mainly expressed in mature germ cells, differentiated embryonic stem cells and germ cell tumors such as teratoma, which suggested that the expression profile of Nr6a1 is spatio-temporal specificity and tissue specificity. To date, a number of upstream or downstream of Nr6a1 regulatory molecules including miR-181a, let7, Oct4, PPARδ have been identified. Through the interactions with these genes, Nr6a1 plays an important regulating role in biological processes of development, cell differentiation and metabolism.