神经干细胞(neural stem cell, NSC)是脑内新生细胞的源泉, 周期性地在脑内两个重要区域分裂: 脑室和海马。当中枢神经系统(central nervous system, CNS)损伤后, 受损神经元胞外微环境含有大量阻止神经再生的因子, 导致神经干细胞增殖能力下降。低剂量激光处理(low-level laser treatment, LLLT)作为一种无损伤的新型物理疗法, 能调节机体的多种生物学功能, 为神经干细胞增殖提供一种潜在的治疗方法。我们研究发现低剂量弱激光处理可以促进小鼠海马区的神经干细胞增殖, 并且促进神经干细胞分化为新生的神经元, 这一研究可以成为神经再生的一种新手段, 将为低剂量激光处理治疗阿尔兹海默症在临床上的应用奠定基础。

Neural Stem Cell(NSC)is the source of new cells in the brain, periodically dividing in two important regions of the brain:the ventricles and the hippocampus. When the central nervous system(CNS)is damaged, the damaged neurons release a large number of factors into the extracellular microenvironment and prevent neurogenesis, resulting in decreased proliferation of neural stem cells. Low-level laser treatment(LLLT), as a new physical therapy without damage, can regulate various biological functions of the body and provide a potential treatment for NSC proliferation. Our study found that LLLT can promote the proliferation of neural stem cells in the hippocampus of mice,and prompt NSC to differentiate into new neurons. Altogether,we show that LLLT can be a new treatment for neurogenesis. Moreover, we provide theory foundation for the clinical application of LLLT in Alzheimer’s disease.