This Letter theoretically and experimentally studies the response of photonic switching in a channel-interleaved photonic analog-to-digital converter (PADC) with high sampling rate and wide input frequency range. A figure of merit (FoM) is introduced to evaluate the switching response of the PADC when a dual-output Mach–Zehnder modulator (MZM) serves as the photonic switch to parallelize the sampled pulse train into two channels. After the optimization of the FoM and utilization of the channel-mismatch compensation algorithm, the system bandwidth of PADC is expanded and the signal-to-distortion ratio is enhanced.