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Dual-modal photoacoustic/CT imaging system

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Abstract

Photoacoustic (PA) tomography (PAT) breaks the barrier for high-resolution optical imaging in a strong light-scattering medium, having a great potential for both clinical implementation and small animal studies. However, many organs and tissues lack enough PA contrast or even hinder the propagation of PA waves. Therefore, it is challenging to interpret pure PAT images, especially three-dimensional (3D) PA images for deep tissues, without enough structural information. To overcome this limitation, in this study, we integrated PAT with X-ray computed tomography (CT) in a standalone system. PAT provides optical contrast and CT gives anatomical information. We performed agar, tissue phantom, and animal studies, and the results demonstrated that PAT/CT imaging systems can provide accurate spatial registration of important complementary contrasts.

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DOI:10.3788/col201816.121701

所属栏目:Medical optics and biotechnology

基金项目:This work was funded by the National Key Research and Development Program of China (No. 2017YFE0104200), the National Natural Science Foundation of China (No. 81421004), and the National Key Instrumentation Development Project (No. 2013YQ030651). We thank Mr. Wenzhao Li for helping to diagnose and reduce electrical noise of the system.

收稿日期:2018-08-12

录用日期:2018-10-24

网络出版日期:2018-11-26

作者单位    点击查看

Kaiye Xia:Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Xiaohui Zhai:Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Zhaoheng Xie:Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Kun Zhou:Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Yutao Feng:Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Guangjie Zhang:Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Changhui Li:Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China

联系人作者:Changhui Li(chli@pku.edu.cn)

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引用该论文

Kaiye Xia, Xiaohui Zhai, Zhaoheng Xie, Kun Zhou, Yutao Feng, Guangjie Zhang, Changhui Li, "Dual-modal photoacoustic/CT imaging system," Chinese Optics Letters 16(12), 121701 (2018)

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