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基于光学相干层析技术的术中颈部组织三维成像

Intraoperative Three-Dimensional Imaging of Neck Tissues Based on Optical Coherence Tomography

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摘要

为了在甲状腺手术中辅助医生对切除的颈部组织进行快速的组织学判断, 使用自行搭建的光学相干层析(OCT)系统对行甲状腺切除术及淋巴结清扫术患者的切除组织进行三维成像, 并将其与二维OCT图像以及病理切片进行对比。对21个病例的切除组织分别采集67幅1000 pixel×1000 pixel×630 pixel的高分辨三维OCT图像, 对应6 mm×6 mm×3.8 mm的成像范围。可以从不同角度和不同的内部切面对三维OCT图像进行观察, 能够清楚地辨别成像范围内的甲状腺、甲状旁腺、淋巴结和脂肪组织, 并能够清楚地分辨淋巴结转移病变。高速、高分辨的三维OCT成像为甲状腺手术提供了一种术中病理诊断的方式, 在辅助医生做出手术决策方面具有一定的应用潜力。

Abstract

In order to assist the surgeons in the fast histological inspection of the excised tissues during the thyroid surgery, a home-made optical coherence tomography (OCT) system is used for the three-dimensional (3D) imaging of the excised tissues from the patients receiving the thyroid surgery and lymphadenectomy. The 3D OCT images are also compared with the corresponding two-dimensional OCT images and the histological images. The 67 high-resolution 3D OCT images with 1000 pixel×1000 pixel×630 pixel are acquired from the excised tissues of the 21 patients and the corresponding imaging range is 6 mm×6 mm×3.8 mm. It is convenient to observe the 3D OCT images from different perspectives or cross-sectional planes. The thyroid, parathyroid, lymph node and fat within the imaging range can be clearly identified, and the malignant lesions of lymphatic metastasis can also be distinguished. This high speed and high resolution 3D OCT imaging provides a method for the intraoperative histopathology and is promising to assist the surgeons for their intraoperative decision.

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中图分类号:TN247

DOI:10.3788/aos201939.0117001

所属栏目:医用光学与生物技术

基金项目:国家自然科学基金(61875092, 11374167)、天津市科技支撑重点项目(17YFZCSY00740)

收稿日期:2018-07-30

修改稿日期:2018-08-01

网络出版日期:2018-08-23

作者单位    点击查看

侯方:南开大学现代光学研究所, 天津 300350
杨子晗:南开大学现代光学研究所, 天津 300350
谷文青:天津医科大学肿瘤医院甲状腺颈部肿瘤科, 国家肿瘤临床医学研究中心, 天津市“肿瘤防治”重点实验室, 天津 300060
于洋:天津医科大学肿瘤医院甲状腺颈部肿瘤科, 国家肿瘤临床医学研究中心, 天津市“肿瘤防治”重点实验室, 天津 300060
赵敬柱:天津医科大学肿瘤医院甲状腺颈部肿瘤科, 国家肿瘤临床医学研究中心, 天津市“肿瘤防治”重点实验室, 天津 300060
梁艳梅:南开大学现代光学研究所, 天津 300350

联系人作者:梁艳梅(ymliang@nankai.edu.cn)

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引用该论文

Hou Fang,Yang Zihan,Gu Wenqing,Yu Yang,Zhao Jingzhu,Liang Yanmei. Intraoperative Three-Dimensional Imaging of Neck Tissues Based on Optical Coherence Tomography[J]. Acta Optica Sinica, 2019, 39(1): 0117001

侯方,杨子晗,谷文青,于洋,赵敬柱,梁艳梅. 基于光学相干层析技术的术中颈部组织三维成像[J]. 光学学报, 2019, 39(1): 0117001

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