以激光功率、激光脉冲频率、扫描速度为优化变量,建立了激光离体皮肤组织融合工艺参数的多目标优化模型。基于MATLAB软件,应用第二代非支配排序遗传算法(NSGA-Ⅱ)寻求帕累托最优解集,得到了最优工艺参数,分析了优化目标对工艺参数变化的响应灵敏度。在优化的工艺参数下,测试了切口黏结强度,分析了微观组织。结果表明:切口黏结强度对激光工艺参数具有更高的灵敏度,激光功率对切口黏结强度、组织峰值温度的影响比较显著;所提优化工艺可以实现离体皮肤组织的全层融合,在组织峰值温度降低的情况下,离体皮肤组织切口的黏结强度比单目标优化结果提高了5.6%。

By selecting laser power, laser pulse frequency and scanning speed as optimization variables, we establish a multi-objective optimization model of laser closure process parameters in vitro skin tissue. Based on MATLAB software, we use second generation non-dominant sequencing genetic algorithm (NSGA-II) to find the Pareto optimal solution set, obtain the optimal process parameters, and then analyze the response sensitivity of optimization objectives to the variation of process parameters. Under the optimized process parameters, the tensile strength of the incision is tested and the microstructure is analyzed. The results show that the incision tensile strength has high sensitivity to the laser process parameters, and the laser power has significant effect on the incision tensile strength and the tissue peak temperature. The proposed optimized process can achieve the in vitro skin tissue closure in full-thickness. In the case of tissue peak temperature decreasing, the tensile strength of in vitro skin tissue incision is 5.6% higher than that of single-objective optimization.