制药车间的药物粉尘成为当前一种新的污染源, 其对从业人员的健康有着很大的危害。选用糖尿病药物格列美脲作为研究对象, 通过太赫兹时域光谱(THz-TDS)技术对其纯品制成的压片进行吸收光谱测量, 测量结果显示, 该药物在 0.1～2 THz波段有多个明显的特征吸收峰。将格列美脲生成气溶胶以模拟车间环境, 为了减少水汽的影响, 通过微孔滤膜干燥法和 Nafion膜干燥法分别对其进行干燥处理。结果表明, 与纯品压片的吸收光谱相比, 两种方法都能很好地识别被测物大多数的特征吸收峰, 给制药车间的药物粉尘检测提供了很好的实验参考。

Drug dust in pharmaceutical workshops has become a new source of pollution, and it has great harm to the health of employees. Glimepiride, one of the diabetes drugs, is selected as the research object. The terahertz time-domain spectroscopy(THz-TDS) is used to measure the absorption coefficient of its pure product tablet. It can be seen that there are many obvious characteristic absorption peak for this drug in the frequency band from 0.1 THz to 2 THz. The glimepiride tablets is used to generate aerosols to simulate the workshop environment. In order to reduce the influence of water vapor, it is dried by microfiltration membrane and Nafion membrane drying tube respectively. The result shows that compared with the absorption spectrum of the pure tablet, most of fingerprint peaks of the analytes can be identified by both methods. This result provides a good experimental reference for the drug dust detection in the pharmaceutical workshop.