中国激光, 2019, 46 (5): 0508008, 网络出版: 2019-11-11   

光纤式相干拉曼散射成像光源研究进展 下载: 1442次

Advances in Fiber Laser Sources for Coherent Raman Scattering Microscopy
作者单位
1 上海理工大学光电信息与计算机工程学院, 上海 200093
2 复旦大学应用表面物理国家重点实验室和物理学系, 上海 200433
3 华东师范大学精密光谱科学与技术国家重点实验室, 上海 200062
摘要
相干拉曼散射具有非侵入、无标记、化学特异性的优点,广泛用于生物组织成像、药代动力学等领域。主要介绍了光纤式相干拉曼散射(CRS)成像光源的实现方式及特点,总结了超连续谱展宽、孤子自频移和四波混频技术在提高双色超短脉冲输出功率、调谐范围、光谱分辨率方面的新进展。报道了基于四波混频的光参量振荡技术在产生可调谐双色超短脉冲方面的最新进展,采用全保偏光纤光路和光子晶体光纤,结合色散滤波和偏振操控技术,获得时间自同步、空间自重合、波长可调谐的双色超短脉冲,可实现脂类、蛋白和核酸的非侵入、无标记光谱检测与成像,为实现结构紧凑、使用方便、环境稳定的CRS提供了一个有效的技术途径。
Abstract
Coherent Raman scattering is extensively used in various fields, such as biomedical tissue imaging and pharmacokinetics, because of its significant advantages, including non-invasive detection, label-free operation, and chemical specificity. Further, we introduce the implementation and characteristics of the fiber laser sources for coherent Raman scattering (CRS) microscopy, and review the most recent advances in improving the output power, tuning range, and spectral resolution based on the dual-color synchronized ultrashort pulses via supercontinuum generation, soliton self-frequency shift, and four-wave mixing. Additionally, the latest advances in four-wave-mixing-based fiber optical parametric oscillators are introduced. Subsequently, the temporally synchronized, spatially overlapped, and wavelength-tunable dual-color ultrashort pulses are obtained based on dispersion filtering and polarization manipulation using the polarization-maintaining fiber and the photonic crystal fiber. Furthermore, the generated laser pulses can be used to achieve non-invasive as well as label-free spectroscopic detection and microscopic imaging for lipids, proteins, and nucleic acid, which could provide an effective methodology to realize compact, user-friendly, and environmentally stable coherent Raman scattering imaging.

郑世凯, 杨康文, 敖建鹏, 叶蓬勃, 郝强, 黄坤, 季敏标, 曾和平. 光纤式相干拉曼散射成像光源研究进展[J]. 中国激光, 2019, 46(5): 0508008. Shikai Zheng, Kangwen Yang, Jianpeng Ao, Pengbo Ye, Qiang Hao, Kun Huang, Minbiao Ji, Heping Zeng. Advances in Fiber Laser Sources for Coherent Raman Scattering Microscopy[J]. Chinese Journal of Lasers, 2019, 46(5): 0508008.

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