表面增强拉曼散射(SERS)是一种先进的表面分析技术, 可以极大提高吸附在金属表面或附近分子的拉曼散射信号。 SERS技术由于其快速准确、 灵敏度高、 选择性好、 样品制备要求低等特点, 成为当前的研究热点, 在化学、 食品、 生物、 医疗等领域展现出重要的应用前景。 而利用SERS技术作为一种常规分析和诊断工具面临的一个主要挑战是如何制备均匀、 可重复、 稳定的活性基底。 打印技术操作简单、 效率高、 成本低, 有助于设计等离激元纳米结构。 通过优化“热点”增强电磁场, 获得重复性好、 稳定性高、 增强能力强的SERS活性基底。 近年来, 印刷技术逐渐被应用于SERS基底的制备。 主要综述了制备SERS基底的几种常用印刷技术, 包括喷墨印刷、 凹版印刷、 丝网印刷等。 分析了衬底表面润湿性、 干燥温度、 油墨粘度、 表面张力、 溶剂等因素对SERS性能的影响。 总结了印刷技术制备SERS基底的研究进展, 并对其潜在应用和未来发展作了展望。

Surface enhanced Raman scattering (SERS) is an advanced surface analysis technique that can enhance the vibrational spectrum of molecules adsorbed on or in the vicinity of metal surfaces enormously. Due to its high speed, accuracy, high sensitivity, good selectivity and minimum requirements for sample preparation, SERS technique becomes the current research hotspot and shows important application prospects in the fields of chemistry, food, biology, medical treatment, etc. However, it is known that the uniformity, reproducibility and stability of SERS active substrates are still main challenges to be overcome for the use of SERS technique as a routine analytical tool .The printing methods have the advantages of simple operation,high efficiency and low cost, which are useful for designing plasmonic nanostructures. In recent years,printing technologies have been gradually applied to the preparation of SERS substrates. By optimizing the amount of hot spots to enhance the electromagnetic field, SERS active substrate with good repeatability, high stability and strong enhancement ability can be obtained. In this work, several common printing techniques for preparing SERS substrates are reviewed,including inkjet printing,gravure printing andscreen printing. The influence of factors on SERS performance is analyzed, such as surface wettability of substrate,drying temperature, ink viscosity, surface tension and solvent. The research progresses of preparing SERS substrates by printing technologies are summarized, and the potential applications and future development are also prospected.