光学学报, 2020, 40 (4): 0430001, 网络出版: 2020-02-11
基于太赫兹时域光谱系统的脑缺血检测 下载: 1123次封面文章
Detection of Cerebral Ischemia Based on Terahertz Time-Domain Spectroscopy
太赫兹时域光谱系统 脑缺血 吸收系数 相对差异 新鲜组织 石蜡包埋组织 terahertz time-domain spectroscopy cerebral ischemia absorption coefficient relative difference fresh tissue paraffin-embedded tissue
摘要
脑缺血是神经外科的常见疾病之一,目前急需一种快速、准确的脑缺血检测方法。利用透射式太赫兹时域光谱技术对脑缺血组织进行检测,为减小个体差异的影响,通过计算左脑与右脑的太赫兹吸收系数的相对差异研究脑组织的缺血程度。实验发现,随着缺血时间的增加,新鲜组织的左右脑吸收系数的相对差异先变大后减小,主要原因是缺血区域的水含量升高和细胞密度下降;而石蜡包埋的脑缺血组织的左右脑吸收系数的相对差异逐渐减小,主要原因是缺血区域的细胞密度逐渐下降。结果表明,利用太赫兹时域光谱系统可以实现最早缺血2 h的脑缺血组织的检测,为脑缺血的早期无标记快速诊断提供了有效的技术手段。
Abstract
Cerebral ischemia is one of the common diseases in neurosurgery, and a rapid and accurate method for cerebral ischemia detection is urgently needed. Transmissive terahertz time-domain spectroscopy is applied to detect cerebral ischemic tissue. In order to reduce the impact of individual differences, the degree of ischemia of brain tissue is studied by calculating the relative difference of the terahertz absorption coefficients between left and right brains. It is found that with the increase of ischemia time, the relative difference of absorption coefficient between left and right brains of fresh tissue first increases and then decreases, which is mainly caused by the increase of water content and the decrease of cell density in the ischemic area; meanwhile, the relative difference of absorption coefficient between left and right brains of paraffin-embedded cerebral ischemic tissue gradually decreases, which is mainly due to the gradual decrease of cell density in the ischemic region. The results show that the terahertz time-domain spectroscopy system can be used to detect the earliest 2 h cerebral ischemia, which provides an effective technical means for the early label free rapid diagnosis of cerebral ischemia.
王与烨, 孙忠成, 徐德刚, 姜智南, 穆宁, 杨川燕, 陈图南, 冯华, 姚建铨. 基于太赫兹时域光谱系统的脑缺血检测[J]. 光学学报, 2020, 40(4): 0430001. Wang Yuye, Sun Zhongcheng, Xu Degang, Jiang Zhinan, Mu Ning, Yang Chuanyan, Chen Tunan, Feng Hua, Yao Jianquan. Detection of Cerebral Ischemia Based on Terahertz Time-Domain Spectroscopy[J]. Acta Optica Sinica, 2020, 40(4): 0430001.