中国激光, 2020, 47 (2): 0207001, 网络出版: 2020-02-21
非标记、定量化穆勒矩阵偏振成像在辅助临床诊断中的应用 下载: 1524次特邀综述
Mueller Matrix Polarimetry: A Label-Free, Quantitative Optical Method for Clinical Diagnosis
医用光学 穆勒矩阵 偏振测定 散射 微观结构 生物医学 medical optics Mueller matrix polarimetry scattering microstructure biomedicine
摘要
近年来,随着新型光学器件的出现与数据处理能力的提升,偏振光学成像技术在生物医学领域的应用逐渐增多。穆勒矩阵因可以完备地表述样品的偏振信息,且测量装置可与传统光学仪器兼容,非常适合于生物医学样品的研究。同时,与非偏振光学方法相比,穆勒矩阵对亚波长结构敏感,还可以额外提供包括双折射、二向色性在内的样品的光学各向异性信息。介绍了穆勒矩阵偏振成像的基本理论与装置,包括穆勒矩阵参量的提取、背向散射成像、偏振显微成像、偏振内窥与偏振染色等在生物医学检测中具有一定应用潜力的方法和技术,并展示了穆勒矩阵成像在肝癌、乳腺癌、胃肠肿瘤等多种病理组织辅助诊断中的最新研究进展。穆勒矩阵偏振成像作为一种非标记、定量化、无损伤的快速检测技术,在生物医学领域显示出了广阔的应用前景。
Abstract
Of late, with the emergence of new optical devices and technological advances in data processing, polarization techniques are being increasingly used in biomedicine. Mueller matrix calculus is suitable for describing the polarization properties of biomedical specimens because of its mathematical completeness and compatibility with common optical equipment. Compared with traditional non-polarization optical methods, Mueller matrix polarimetry is sensitive to the scattering induced by subwavelength structures and can provide more information about anisotropic optical properties, including the birefringence and diattenuation of a sample. In this review, we introduce Mueller matrix calculus and related technologies that have great application potential in biomedical studies, including the Mueller matrix decomposition and transformation methods, transmission Mueller matrix microscopes, backscattering Mueller matrix imaging equipment, Mueller matrix endoscopes, and polarization staining techniques. Further, we summarize the improvements in clinical diagnosis made using Mueller matrix polarimetry, such as detection of liver cancer, gastrointestinal cancer, and breast ductal carcinoma tissues. As a label-free, noninvasive, quantitative, and rapid imaging method, Mueller matrix polarimetry has broad application prospects in biomedical studies and clinical diagnosis.
沈元星, 姚悦, 何宏辉, 刘少雄, 马辉. 非标记、定量化穆勒矩阵偏振成像在辅助临床诊断中的应用[J]. 中国激光, 2020, 47(2): 0207001. Shen Yuanxing, Yao Yue, He Honghui, Liu Shaoxiong, Ma Hui. Mueller Matrix Polarimetry: A Label-Free, Quantitative Optical Method for Clinical Diagnosis[J]. Chinese Journal of Lasers, 2020, 47(2): 0207001.