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发光二极管在光动力疗法中的应用进展 (封面文章) (特邀综述)

Application Progress of Light-Emitting Diode for Photodynamic Therapy (Cover Paper) (Invited)

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摘要

光动力疗法(PDT)是一种联合利用光敏剂、光和氧分子,通过光动力反应选择性治疗恶性肿瘤和良性疾病的微创疗法。光源作为PDT的三大关键要素之一,其发光波长、照光方式以及剂量直接决定PDT疗效。针对临床治疗对光源的性能需求,探讨了发光二极管(LED)作为PDT光源的技术优势。深入介绍了LED阵列光源,以及用于发展可穿戴式、可植入式新型PDT光源的有机LED、量子点LED和无线驱动LED的研究进展。全面总结了LED在离体细胞、活体动物以及临床PDT等方面的应用现状。研发波长可切换的多波长LED并实现照光区域和剂量的实时调控是未来智能个性化PDT光源的发展趋势。

Abstract

Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that can selectively treat malignant and benign diseases by using a combination of photosensitizers, light, and oxygen molecules. The light source is one of the three key elements of PDT, and its emission wavelength, irradiation method, and dose directly determine the efficiency of PDT. According to the required performances of light sources for clinical treatment, the technical advantages of light-emitting diode (LED) as light source in PDT applications are discussed. The LED array light source, and the development of wearable and implantable novel PDT light sources based on the organic LED, quantum dot LED, and wireless powered LED are introduced in depth. The application status of LED in isolated cells, live animals, and clinical PDT is summarized comprehensively. The development of LEDs with tunable emission wavelengths and the real-time adjustment of the illumination area and dose are the future development trends of intelligent and personalized PDT light sources.

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中图分类号:R454.2

DOI:10.3788/LOP57.150001

所属栏目:综述

基金项目:国家自然科学基金;

收稿日期:2020-03-13

修改稿日期:2020-04-01

网络出版日期:2020-08-01

作者单位    点击查看

林立:福建师范大学医学光电科学与技术教育部重点实验室, 福建省光子技术重点实验室, 福建 福州 350007
李步洪:福建师范大学医学光电科学与技术教育部重点实验室, 福建省光子技术重点实验室, 福建 福州 350007

联系人作者:林立(lilin@fjnu.edu.cn); 李步洪(bhli@fjnu.edu.cn);

备注:国家自然科学基金;

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引用该论文

Lin Li,Li Buhong. Application Progress of Light-Emitting Diode for Photodynamic Therapy[J]. Laser & Optoelectronics Progress, 2020, 57(15): 150001

林立,李步洪. 发光二极管在光动力疗法中的应用进展[J]. 激光与光电子学进展, 2020, 57(15): 150001

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