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一种多通道扩散相关拓扑成像系统及方法

Multichannel Diffuse Correlation Spectroscopy Topography System

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摘要

扩散相关光谱法(DCS)是一种新兴的无创检测组织深层血流流速变化的光学方法。开发了一种基于多时延光子相关器的多通道DCS拓扑成像系统,该系统主要包含长相干激光器、光子计数式光电倍增管和光子相关器。多时延光子相关器结构可以保证光强时间自相关曲线的高分辨率和大动态范围。结合该系统的成像特点,将基于相关扩散方程解析解的约束非线性优化算法作为模型,实现半无限空间条件下相关扩散方程解析解与实验测得的相关曲线的最佳匹配,以计算血流指数。动态仿体实验验证了该系统可以分辨液体介质的流速,且可以重建出不同流速的二维图像。

Abstract

Diffuse correlation spectroscopy (DCS) is a rapidly growing optical technology to noninvasively assess the tissue blood flow index. We develop a multichannel DCS topography system based on a multi-tau photon correlator, which comprises a long coherence length laser, a photomultiplier tube, and a photon correlator. The multi-tau photon correlator structure can obtain the intensity temporal correlation curve with high resolution and large dynamic range. Combining the imaging characteristics of the system, the constrained nonlinear optimization algorithm based on the analytical solution of the correlation diffusion equation is used as the model. The model is applied to match data between actual measurements and model predictions calculated by analytically solving the correlation diffusion equation in semi-infinite geometry. Finally, the dynamic phantom experiments demonstrate that the imaging system can distinguish different flow rates of liquid medium to reconstruct a two-dimensional image of flow rate distribution.

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DOI:10.3788/CJL201946.0907002

所属栏目:生物医学光子学与激光医学

基金项目:国家自然科学基金、天津市自然科学基金;

收稿日期:2019-04-11

修改稿日期:2019-05-21

网络出版日期:2019-09-01

作者单位    点击查看

回子帆:天津大学精密仪器与光电子工程学院, 天津 300072
谢锦斌:天津大学精密仪器与光电子工程学院, 天津 300072
何向东:天津大学精密仪器与光电子工程学院, 天津 300072
秦转萍:天津职业技术师范大学自动化与电气工程学院, 天津 300222
高峰:天津大学精密仪器与光电子工程学院, 天津 300072天津市生物医学检测技术与仪器重点实验室, 天津 300072

联系人作者:回子帆(bme_huizf@tju.edu.cn); 秦转萍( qzp2013@tute.edu.cn); 高峰( gaofeng@tju.edu.cn);

备注:国家自然科学基金、天津市自然科学基金;

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引用该论文

Zifan Hui,Jinbin Xie,Xiangdong He,Zhuanping Qin,Feng Gao. Multichannel Diffuse Correlation Spectroscopy Topography System[J]. Chinese Journal of Lasers, 2019, 46(9): 0907002

回子帆,谢锦斌,何向东,秦转萍,高峰. 一种多通道扩散相关拓扑成像系统及方法[J]. 中国激光, 2019, 46(9): 0907002

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