Photonics Research, 2020, 8 (7): 07001253, Published Online: Jun. 30, 2020
Portable quantitative phase microscope for material metrology and biological imaging Download: 761次
Abstract
Quantitative phase microscopy (QPM) has emerged as an important tool for material metrology and biological imaging. For broader adoption in those applications, we have proposed and demonstrated a new portable off-axis QPM method, which works in both transmission and reflection modes to meet different sample measurement requirements. The temporal and spatial sensitivities of our system, as quantified by optical path-length difference values, are 0.65 nm and 1.04 nm, respectively. To demonstrate its applicability for a wide range of applications, we deployed our system for profiling transistor gold electrode samples, observing red blood cell membrane fluctuations, imaging living cells flowing in a microfluidic chip, etc. Our portable QPM system has a low-cost design and involves a simple and robust phase-retrieval algorithm that we envision will allow for broader deployment at different environmental settings, including in resource-limited sites and integration with other metrology or imaging modalities.
Mengxuan Niu, Gang Luo, Xin Shu, Fuyang Qu, Shuang Zhou, Yi-Ping Ho, Ni Zhao, Renjie Zhou. Portable quantitative phase microscope for material metrology and biological imaging[J]. Photonics Research, 2020, 8(7): 07001253.