首页 > 论文 > 光学学报 > 39卷 > 10期(pp:1030003--1)

同型半胱氨酸的太赫兹特征吸收光谱分析

Terahertz Characteristic Absorption Spectrometric Analysis of Homocysteine

  • 摘要
  • 论文信息
  • 参考文献
  • 被引情况
  • PDF全文
分享:

摘要

同型半胱氨酸(C4H9NO2S)是一种含硫氨基酸,对人体有害,其在人体内的含量过多时会成为心血管疾病、冠心病、糖尿病及并发症、老年痴呆等疾病的致病因子[1-3]。目前,医学上对同型半胱氨酸的检测方法主要有高效液相色谱检测法(HPLC)、荧光极化免疫法(FPIA)和酶联免疫吸附法(ELISA)3种。这3种方法都存在检测耗时、成本昂贵等缺点。

Abstract

We investigate the terahertz characteristic absorption spectra of homocysteine. First, we use the density functional theory to analyze the vibration and rotation modes of homocysteine and ensure that the theoretical absorption peak is within the testing range of the terahertz spectroscopy system. Subsequently, the characteristic absorption spectra of homocysteine with different concentration are measured based on the terahertz time-domain spectroscopy system, which can be accurately performed using the linear fitting equation. These results exhibit considerable significance for the accurate and rapid diagnosis of homocysteine-related diseases in clinical medicine.

Newport宣传-MKS新实验室计划
补充资料

DOI:10.3788/AOS201939.1030003

所属栏目:光谱学

基金项目:国家重点研发计划重点专项、国家自然科学基金、上海市启明星人才计划、上海市教育发展基金会“曙光计划”、上海市青年拔尖人才开发计划;

收稿日期:2019-05-20

修改稿日期:2019-06-25

网络出版日期:2019-10-01

作者单位    点击查看

王莹莹:上海理工大学光电信息科学与计算机工程学院, 上海 200093上海市现代光学系统重点实验室, 上海 200093
汪丽平:上海理工大学光电信息科学与计算机工程学院, 上海 200093上海市现代光学系统重点实验室, 上海 200093
李恬:上海理工大学光电信息科学与计算机工程学院, 上海 200093上海市现代光学系统重点实验室, 上海 200093
严俊:上海理工大学光电信息科学与计算机工程学院, 上海 200093上海市现代光学系统重点实验室, 上海 200093
彭滟:上海理工大学光电信息科学与计算机工程学院, 上海 200093上海市现代光学系统重点实验室, 上海 200093

联系人作者:彭滟(py@usst.edu.cn)

备注:国家重点研发计划重点专项、国家自然科学基金、上海市启明星人才计划、上海市教育发展基金会“曙光计划”、上海市青年拔尖人才开发计划;

【1】Yi Z Q, Peng M A, Wan F F et al. The relationship between hyperhomocysteine and senile diabetes mellitus and coronary heart disease. Chinese Journal of Gerontology. 39(7), 1576-1577(2019).
易志强, 彭民安, 万凤福 等. 高同型半胱氨酸与老年糖尿病及冠心病的关系. 中国老年学杂志. 39(7), 1576-1577(2019).

【2】Feng J, Huang M, Ni H et al. Influence of bone healing by homocysteine levels on patients with limb fracture. Chinese Journal of Traditional Medical Traumatology & Orthopedics. 23(7), 38-41(2015).
冯晶, 黄觅, 倪欢 等. 同型半胱氨酸水平对四肢骨折愈合的影响. 中国中医骨伤科杂志. 23(7), 38-41(2015).

【3】Qi J. Study on the correlation between plasma homocysteine level and the severity of alzheimer''''s disease. Electronic Journal of Clinical Medical Literature. 5(41), 34-35(2018).
戚杰. 血浆同型半胱氨酸水平与老年痴呆病情程度的相关性研究. 临床医药文献电子杂志. 5(41), 34-35(2018).

【4】Ajito K and Ueno Y. THz chemical imaging for biological applications. IEEE Transactions on Terahertz Science and Technology. 1(1), 293-300(2011).

【5】Huang R R, Zhao G Z, Liu Y et al. Study of terahertz and infrared spectra of four kinds of lactose. Acta Optica Sinica. 35(s2), (2015).
黄瑞瑞, 赵国忠, 刘影 等. 4种乳糖的太赫兹光谱和红外光谱特性研究. 光学学报. 35(s2), (2015).

【6】Zhong H, Redo-Sanchez A and Zhang X C. Identification and classification of chemicals using terahertz reflective spectroscopic focal-plane imaging system. Optics Express. 14(20), 9130-9141(2006).

【7】Zeitler J A, Newnham D A, Taday P F et al. Temperature dependent terahertz pulsed spectroscopy of carbamazepine. Thermochimica Acta. 436(1/2), 71-77(2005).

【8】Nishizawa J I, Sasaki T, Suto K et al. THz transmittance measurements of nucleobases and related molecules in the 0.4- to 5.8-THz region using a GaP THz wave generator. Optics Communications. 246(1/2/3), 229-239(2005).

【9】Sun J H, Shen J L, Liang L S et al. Experimental investigation on terahertz spectra of amphetamine type stimulants. Chinese Physics Letters. 22(12), 3176-3178(2005).

【10】Zheng X M. McLaughlin C V, Cunningham P, et al. Organic broadband terahertz sources and sensors. Journal of Nanoelectronics and Optoelectronics. 2(1), 58-76(2007).

【11】Feng R S, Li W W, Zhou Q L et al. Terahertz spectroscopic investigations of explosives and the related compounds. Proceedings of SPIE. 7158, (2009).

【12】Peng Y, Yuan X R, Zou X et al. Terahertz identification and quantification of neurotransmitter and neurotrophy mixture. Biomedical Optics Express. 7(11), 4472-4479(2016).

【13】Auston D H and Smith P R. Generation and detection of millimeter waves by picosecond photoconductivity. Applied Physics Letters. 43(7), 631-633(1983).

【14】Auston D H and Cheung K P. Coherent time-domain far-infrared spectroscopy. Journal of the Optical Society of America B. 2(4), 606-612(1985).

【15】Xu L, Zhang X C and Auston D H. Terahertz beam generation by femtosecond optical pulses in electro-optic materials. Applied Physics Letters. 61(15), 1784-1786(1992).

【16】Hu B B, Zhang X C, Auston D H et al. Free-space radiation from electro-optic crystals. Applied Physics Letters. 56(6), 506-508(1990).

【17】Xie X, Dai J M and Zhang X C. Coherent control of THz wave generation in ambient air. Physical Review Letters. 96(7), (2006).

【18】Tanoto H, Teng J H, Wu Q Y et al. Nano-antenna in a photoconductive photomixer for highly efficient continuous wave terahertz emission. Scientific Reports. 3, (2013).

【19】Peng Y, Shi C J, Xu M Q et al. Qualitative and quantitative identification of components in mixture by terahertz spectroscopy. IEEE Transactions on Terahertz Science and Technology. 8(6), 696-701(2018).

【20】Chen W Q, Peng Y, Jiang X K et al. Isomers identification of 2-hydroxyglutarate acid disodium salt (2HG) by terahertz time-domain spectroscopy. Scientific Reports. 7, (2017).

【21】Ueno Y, Rungsawang R, Tomita I et al. Quantitative measurements of amino acids by terahertz time-domain transmission spectroscopy. Analytical Chemistry. 78(15), 5424-5428(2006).

引用该论文

Yingying Wang,Liping Wang,Tian Li,Jun Yan,Yan Peng. Terahertz Characteristic Absorption Spectrometric Analysis of Homocysteine[J]. Acta Optica Sinica, 2019, 39(10): 1030003

王莹莹,汪丽平,李恬,严俊,彭滟. 同型半胱氨酸的太赫兹特征吸收光谱分析[J]. 光学学报, 2019, 39(10): 1030003

您的浏览器不支持PDF插件,请使用最新的(Chrome/Fire Fox等)浏览器.或者您还可以点击此处下载该论文PDF