中国激光, 2019, 46 (8): 0807001, 网络出版: 2019-08-13
基于各向异性光吸收的线偏振光声成像 下载: 1148次
Linearly Polarized Photoacoustic Imaging Based on Anisotropic Optical Absorption
生物光学 光声成像 线偏振光 各向异性 吸收差异 biotechnology photoacoustic imaging linearly polarized light anisotropy absorption difference
摘要
为解决传统的光声成像技术通常将组织的吸收系数假定为无方向性的标量常数而忽略组织各向异性光吸收特性的问题,利用两束电矢量方向相互垂直的线偏振光作为光声成像的激发源,提出一种基于各向异性光吸收的线偏振光声成像技术;搭建线偏振光光声显微成像系统,并选取具有各向异性光吸收差异的材料作为样品,对所提技术的可行性进行实验验证;进一步对生物样品进行成像,演示所提技术对各向异性光吸收生物样本的成像能力。结果表明,所提技术易植入传统的光声显微成像系统中,拓展了传统光声成像的信息提取范围。
Abstract
In conventional photoacoustic (PA) imaging, the tissue absorption coefficient is usually considered to be a non-directional scalar constant, and its anisotropic optical absorption characteristics are ignored. Herein, we propose an anisotropic PA microscopy (A-PAM) technique that uses two linearly polarized light beams perpendicular to each other as the excitation source for PA imaging. Subsequently, we develop the A-PAM imaging system and verify the feasibility of the proposed method using phantoms that exhibit different forms of anisotropic optical absorption. Furthermore, we demonstrate the imaging ability of this method using biological samples that exhibit anisotropic absorption. Results show that the proposed method can be easily implanted into the conventional PAM imaging system, expanding the range of information extracted using conventional PA imaging.
石玉娇, 张振辉. 基于各向异性光吸收的线偏振光声成像[J]. 中国激光, 2019, 46(8): 0807001. Yujiao Shi, Zhenhui Zhang. Linearly Polarized Photoacoustic Imaging Based on Anisotropic Optical Absorption[J]. Chinese Journal of Lasers, 2019, 46(8): 0807001.