首页 > 论文 > 中国激光 > 47卷 > 11期(pp:1102007--1)

纳秒激光诱导表面微纳结构对锆基金属玻璃生物兼容性的影响

Effect of Nanosecond Laser-Induced Micro-Nanostructures on Biocompatibility of Zr-Based Bulk Metallic Glasses

  • 摘要
  • 论文信息
  • 参考文献
  • 被引情况
  • PDF全文
分享:

摘要

针对医用植入体材料锆基金属玻璃在应用中存在的生物兼容性问题,采用纳秒激光在金属玻璃试样表面诱导产生点阵和沟槽两种微纳结构,然后采用细胞活性测试、细胞分布和形态观察评价两种微纳结构对锆基金属玻璃生物兼容性的改善效果,并从表面形貌方面讨论激光表面改性对生物兼容性的改善机理。结果表明:相对于原始试样,激光诱导产生的沟槽结构能够显著增强成骨细胞在试样表面的黏附性和细胞活性,这主要归功于显著增加的表面粗糙度;点阵结构对细胞活性的改善效果不理想。除此之外,在沟槽试样表面,激光诱导产生的沟槽以及在沟槽内附着的微纳结构是成骨细胞在沟槽内部或附近沿着沟槽方向分布的主要原因。

Abstract

In an effort to resolve the biocompatibility problems of Zr-based bulk metallic glasses in biomedical applications as implant materials, a nanosecond laser was employed to produce dimple and groove textures on a Zr sample surface. The biocompatibility characteristics of the sample surface were evaluated by a cell viability test, cell alignment, and morphology observation. Moreover, the surface modifications induced biocompatibility enhancement mechanism were discussed from the perspective of the surface morphology evolution. The results show that, compared with an untreated sample, the laser-induced groove pattern could significantly enhance osteoblast adhesion on the sample surface and cell viability, which is mainly attributed to the remarkably improved surface roughness. However, the modification effect of the laser-induced dimple pattern on cell viability was undesirable. In addition, the laser-induced grooves and the micro-nanostructures attached in the grooves are the main reasons why the osteoblasts are distributed along the groove direction in or around the grooves.

广告组1 - 空间光调制器+DMD
补充资料

中图分类号:TG665

DOI:10.3788/CJL202047.1102007

所属栏目:激光制造

基金项目:广东省重点领域研发计划、国家自然科学基金、国家重点研发计划;

收稿日期:2020-05-18

修改稿日期:2020-07-16

网络出版日期:2020-11-01

作者单位    点击查看

焦阳:空军工程大学航空工程学院等离子体动力学重点实验室, 陕西 西安 710043
何卫锋:空军工程大学航空工程学院等离子体动力学重点实验室, 陕西 西安 710043
上官龙:陕西省泾阳县医院骨科, 陕西 咸阳 713700
周留成:空军工程大学航空工程学院等离子体动力学重点实验室, 陕西 西安 710043
罗思海:空军工程大学航空工程学院等离子体动力学重点实验室, 陕西 西安 710043
聂祥樊:空军工程大学航空工程学院等离子体动力学重点实验室, 陕西 西安 710043

联系人作者:焦阳(young_joeafeu@163.com)

备注:广东省重点领域研发计划、国家自然科学基金、国家重点研发计划;

【1】Demetriou M D, Wiest A, Hofmann D C, et al. Amorphous metals for hard-tissue prosthesis [J]. JOM. 2010, 62(2): 83-91.Demetriou M D, Wiest A, Hofmann D C, et al. Amorphous metals for hard-tissue prosthesis [J]. JOM. 2010, 62(2): 83-91.

【2】Long W J, Nayyar S, Chen K K, et al. Early aseptic loosening of the Tritanium primary acetabular component with screw fixation [J]. Arthroplasty Today. 2018, 4(2): 169-174.Long W J, Nayyar S, Chen K K, et al. Early aseptic loosening of the Tritanium primary acetabular component with screw fixation [J]. Arthroplasty Today. 2018, 4(2): 169-174.

【3】Igarashi K, Afrashtehfar K I. Clinical assessment of fractured implant abutment screws: the Bernese silicone replica technique [J]. The Journal of Prosthetic Dentistry. 2018, 119(5): 717-719.Igarashi K, Afrashtehfar K I. Clinical assessment of fractured implant abutment screws: the Bernese silicone replica technique [J]. The Journal of Prosthetic Dentistry. 2018, 119(5): 717-719.

【4】Meagher P. O''''Cearbhaill E D, Byrne J H, et al. Bulk metallic glasses for implantable medical devices and surgical tools [J]. Advanced Materials. 2016, 28(27): 5755-5762.

【5】Li H F, Zheng Y F. Recent advances in bulk metallic glasses for biomedical applications [J]. Acta Biomaterialia. 2016, 36: 1-20.Li H F, Zheng Y F. Recent advances in bulk metallic glasses for biomedical applications [J]. Acta Biomaterialia. 2016, 36: 1-20.

【6】Kumari R, Scharnweber T, Pfleging W, et al. Laser surface textured titanium alloy (Ti-6Al-4V) - Part II - studies on bio-compatibility [J]. Applied Surface Science. 2015, 357: 750-758.Kumari R, Scharnweber T, Pfleging W, et al. Laser surface textured titanium alloy (Ti-6Al-4V) - Part II - studies on bio-compatibility [J]. Applied Surface Science. 2015, 357: 750-758.

【7】Yang Y Z, Kim K H, Ong J L. A review on calcium phosphate coatings produced using a sputtering process: an alternative to plasma spraying [J]. Biomaterials. 2005, 26(3): 327-337.Yang Y Z, Kim K H, Ong J L. A review on calcium phosphate coatings produced using a sputtering process: an alternative to plasma spraying [J]. Biomaterials. 2005, 26(3): 327-337.

【8】Rautray T R, Narayanan R, Kim K H. Ion implantation of titanium based biomaterials [J]. Progress in Materials Science. 2011, 56(8): 1137-1177.

【9】Villapún V M, Qu B K, Lund P A, et al. Optimizing the antimicrobial performance of metallic glass composites through surface texturing [J]. Materials Today Communications. 2020, 23: 101074.

【10】Bao Y M, Wang C W, Jin Z W, et al. Textured surface on a bioceramic coating via a femtosecond laser and its friction and wear properties [J]. Chinese Journal of Lasers. 2019, 46(2): 0203003.
鲍雨梅, 王成武, 金志伟, 等. 激光表面织构化生物陶瓷涂层及其摩擦磨损性能 [J]. 中国激光. 2019, 46(2): 0203003.

【11】Jiang C Y, Wang C Y, Luo K Y, et al. Effects of laser shock layer number and Cl-concentration on anticorrosion behaviors of AM50 Mg alloys [J]. Chinese Journal of Lasers. 2018, 45(9): 0902004.
江崇远, 王长雨, 罗开玉, 等. 激光冲击层数和氯离子浓度对AM50镁合金耐腐蚀性能的影响 [J]. 中国激光. 2018, 45(9): 0902004.

【12】Wei J, Zhang B, Liu H, et al. Time-resolved shadowgraphic imaging of femtosecond laser ablated micro-holes in silica glass [J]. Chinese Journal of Lasers. 2019, 46(5): 0508020.
魏健, 张彬, 刘晖, 等. 飞秒激光烧蚀石英微孔的时间分辨阴影成像 [J]. 中国激光. 2019, 46(5): 0508020.

【13】Chen J, Mwenifumbo S, Langhammer C, et al. Cell/surface interactions and adhesion on Ti-6Al-4V: effects of surface texture [J]. Journal of Biomedical Materials Research Part B. 2007, 82(2): 360-373.

【14】Ohtsu N, Kozuka T, Yamane M, et al. Surface chemistry and osteoblast-like cell response on a titanium surface modified by a focused Nd∶YAG laser [J]. Surface and Coatings Technology. 2017, 309: 220-226.Ohtsu N, Kozuka T, Yamane M, et al. Surface chemistry and osteoblast-like cell response on a titanium surface modified by a focused Nd∶YAG laser [J]. Surface and Coatings Technology. 2017, 309: 220-226.

【15】Jiao Y, Brousseau E, Han Q Q, et al. Investigations in nanosecond laser micromachining on the Zr52.8Cu17.6Ni14.8Al9.9Ti4.9 bulk metallic glass: experimental and theoretical study [J]. Journal of Materials Processing Technology. 2019, 273: 116232.

【16】Cai Y K, Chang W L, Luo X C, et al. Superhydrophobic structures on 316L stainless steel surfaces machined by nanosecond pulsed laser [J]. Precision Engineering. 2018, 52: 266-275.

【17】Li J, Shi L L, Zhu Z D, et al. Zr61Ti2Cu25Al12 metallic glass for potential use in dental implants: biocompatibility assessment by in vitro cellular responses [J]. Materials Science and Engineering C. 2013, 33(4): 2113-2121.

【18】Revathi A, Das M, Balla V K, et al. Surface engineering of LENS-Ti-6Al-4V to obtain nano- and micro-surface topography for orthopedic application [J]. Nanomedicine: Nanotechnology, Biology and Medicine. 2019, 18: 157-168.Revathi A, Das M, Balla V K, et al. Surface engineering of LENS-Ti-6Al-4V to obtain nano- and micro-surface topography for orthopedic application [J]. Nanomedicine: Nanotechnology, Biology and Medicine. 2019, 18: 157-168.

【19】Huang L, Cao Z, Meyer H M, et al. Responses of bone-forming cells on pre-immersed Zr-based bulk metallic glasses: effects of composition and roughness [J]. Acta Biomaterialia. 2011, 7(1): 395-405.

【20】Chen J, Ulerich J P, Abelev E, et al. An investigation of the initial attachment and orientation of osteoblast-like cells on laser grooved Ti-6Al-4V surfaces [J]. Materials Science and Engineering C. 2009, 29(4): 1442-1452.

引用该论文

Jiao Yang,He Weifeng,Shangguan Long,Zhou Liucheng,Luo Sihai,Nie Xiangfan. Effect of Nanosecond Laser-Induced Micro-Nanostructures on Biocompatibility of Zr-Based Bulk Metallic Glasses[J]. Chinese Journal of Lasers, 2020, 47(11): 1102007

焦阳,何卫锋,上官龙,周留成,罗思海,聂祥樊. 纳秒激光诱导表面微纳结构对锆基金属玻璃生物兼容性的影响[J]. 中国激光, 2020, 47(11): 1102007

您的浏览器不支持PDF插件,请使用最新的(Chrome/Fire Fox等)浏览器.或者您还可以点击此处下载该论文PDF