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基于改进半阈值法的生物发光断层成像仿真

Simulation of Bioluminescence Tomography Based on Improved Half Threshold Algorithm

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摘要

提出将百分位半阈值匹配追踪法(PHTPA)应用于生物发光断层成像(BLT)这一光学分子成像模态领域。将BLT光源重建为一个L1/2范数正则化问题,在迭代半阈值算法(HTA)的基础上,结合子空间跟踪和百分位阈值法对其求解。在数字鼠模型上设计多组仿真实验,对改进的半阈值算法进行有效性和收敛性的评估。仿真结果表明,与原有的HTA和迭代重赋权算法相比,PHTPA在不同光源设置下都能得到更为准确的重建结果。

Abstract

We propose a percentile half threshold pursuit algorithm (PHTPA) for applying optical molecular imaging modality to bioluminescence tomography (BLT). The BLT reconstruction problem is modeled as an L1/2 regularization problem that can be solved by combining the subspace pursuit (SP) and percentile threshold methods based on the iterative half threshold algorithm (HTA). Several simulations are run on the digital mouse model to evaluate the validity and astringency of PHTPA. The simulation results demonstrate that PHTPA produces more accurate reconstruction results in different source settings when compared with the original HTA and iterative reweighted algorithms.

Newport宣传-MKS新实验室计划
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中图分类号:TP319, Q632

DOI:10.3788/AOS201939.1017001

所属栏目:医用光学与生物技术

基金项目:国家自然科学基金、陕西省国际科技合作与交流计划项目;

收稿日期:2019-03-25

修改稿日期:2019-06-21

网络出版日期:2019-10-01

作者单位    点击查看

方子叶:陕西师范大学物理与信息技术学院, 陕西 西安 710119
余景景:陕西师范大学物理与信息技术学院, 陕西 西安 710119

联系人作者:余景景(yujj@snnu.edu.cn)

备注:国家自然科学基金、陕西省国际科技合作与交流计划项目;

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引用该论文

Fang Ziye,Yu Jingjing. Simulation of Bioluminescence Tomography Based on Improved Half Threshold Algorithm[J]. Acta Optica Sinica, 2019, 39(10): 1017001

方子叶,余景景. 基于改进半阈值法的生物发光断层成像仿真[J]. 光学学报, 2019, 39(10): 1017001

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