Author Affiliations
Abstract
CNR-ISASI Institute of Applied Sciences & Intelligent Systems Viale Campi Flegrei, 34 80078 Pozzuoli (Na), Italy
Advancements are reported in computer-generated holography proofing RGB 4K display through a new strategy based on diffraction model-driven deep networks. In the new 4K-DMDNet, the network is not a “black box” anymore. Rather, the input-output relation must obey to the physics of wavefront propagation, which is embedded here as a constraint. Thus, a labelled dataset is not required, and the model shows superior generalization capabilities with respect to data-driven approaches. The method is promising for the new generation of RGB 4K holographic display, as well as augmented and virtual reality systems.
Opto-Electronic Advances
2024, 7(1): 230176
Keyao Li 1,2†Yiming Wang 3†Dapu Pi 1Baoli Li 1[ ... ]Min Gu 1
Author Affiliations
Abstract
1 Institute of Photonic Chips, University of Shanghai for Science and Technology, Shanghai 200093, China
2 Centre for Artificial-Intelligence Nanophotonics, School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
3 National Laboratory of Solid State Microstructures, and College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China
Secret sharing is a promising technology for information encryption by splitting the secret information into different shares. However, the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is limited. Herein, we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal (LC) holograms. The LC holograms are used as spatially separated shares to carry secret images. The polarization of the incident light and the distance between different shares are served as secret keys, which can significantly improve the information security and capacity. Besides, the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency, which further increases the information security. In implementation, an artificial neural network (ANN) model is developed to carefully design the phase distribution of each LC hologram. With the advantage of high security, high capacity and simple configuration, our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display.
holographic encryption optical secret sharing cascaded liquid crystal hologram multi-dimensional multiplexing 
Opto-Electronic Advances
2024, 7(1): 230121
Yuncheng Liu 1†Ke Xu 1†Xuhao Fan 1Xinger Wang 1[ ... ]Hui Gao 1,2,**
Author Affiliations
Abstract
1 Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China
2 Optics Valley Laboratory, Wuhan 430074, China
Interactive holography offers unmatched levels of immersion and user engagement in the field of future display. Despite of the substantial progress has been made in dynamic meta-holography, the realization of real-time, highly smooth interactive holography remains a significant challenge due to the computational and display frame rate limitations. In this study, we introduced a dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates. To our knowledge, this is the first reported practical dynamic interactive metasurface holographic system. We spatially divided the metasurface device into multiple distinct channels, each projecting a reconstructed sub-pattern. The switching states of these channels were mapped to bitwise operations on a set of bit values, which avoids complex hologram computations, enabling an ultra-high computational frame rate. Our approach achieves a computational frame rate of 800 kHz and a display frame rate of 23 kHz on a low-power Raspberry Pi computational platform. According to this methodology, we demonstrated an interactive dynamic holographic Tetris game system that allows interactive gameplay, color display, and on-the-fly hologram creation. Our technology presents an inspiration for advanced dynamic meta-holography, which is promising for a broad range of applications including advanced human-computer interaction, real-time 3D visualization, and next-generation virtual and augmented reality systems.
interactive display meta-holography bitwise operation ultra-high frame rate 
Opto-Electronic Advances
2024, 7(1): 230108
Wei Yin 1,2,3†Yuxuan Che 1,2,3†Xinsheng Li 1,2,3Mingyu Li 1,2,3[ ... ]Chao Zuo 1,2,3,****
Author Affiliations
Abstract
1 Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
2 Smart Computational Imaging Research Institute (SCIRI) of Nanjing University of Science and Technology, Nanjing 210019, China
3 Jiangsu Key Laboratory of Spectral Imaging & Intelligent Sense, Nanjing 210094, China
4 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China
Recently, deep learning has yielded transformative success across optics and photonics, especially in optical metrology. Deep neural networks (DNNs) with a fully convolutional architecture (e.g., U-Net and its derivatives) have been widely implemented in an end-to-end manner to accomplish various optical metrology tasks, such as fringe denoising, phase unwrapping, and fringe analysis. However, the task of training a DNN to accurately identify an image-to-image transform from massive input and output data pairs seems at best na?ve, as the physical laws governing the image formation or other domain expertise pertaining to the measurement have not yet been fully exploited in current deep learning practice. To this end, we introduce a physics-informed deep learning method for fringe pattern analysis (PI-FPA) to overcome this limit by integrating a lightweight DNN with a learning-enhanced Fourier transform profilometry (LeFTP) module. By parameterizing conventional phase retrieval methods, the LeFTP module embeds the prior knowledge in the network structure and the loss function to directly provide reliable phase results for new types of samples, while circumventing the requirement of collecting a large amount of high-quality data in supervised learning methods. Guided by the initial phase from LeFTP, the phase recovery ability of the lightweight DNN is enhanced to further improve the phase accuracy at a low computational cost compared with existing end-to-end networks. Experimental results demonstrate that PI-FPA enables more accurate and computationally efficient single-shot phase retrieval, exhibiting its excellent generalization to various unseen objects during training. The proposed PI-FPA presents that challenging issues in optical metrology can be potentially overcome through the synergy of physics-priors-based traditional tools and data-driven learning approaches, opening new avenues to achieve fast and accurate single-shot 3D imaging.
optical metrology deep learning physics-informed neural networks fringe analysis phase retrieval 
Opto-Electronic Advances
2024, 7(1): 230034
Author Affiliations
Abstract
1 School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, China
2 Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen 361102, China
3 Institute of Laser Engineering, Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing 100124, China
High-resolution multi-color printing relies upon pixelated optical nanostructures, which is crucial to promote color display by producing nonbleaching colors, yet requires simplicity in fabrication and dynamic switching. Antimony trisulfide (Sb2S3) is a newly rising chalcogenide material that possesses prompt and significant transition of its optical characteristics in the visible region between amorphous and crystalline phases, which holds the key to color-varying devices. Herein, we proposed a dynamically switchable color printing method using Sb2S3-based stepwise pixelated Fabry-Pérot (FP) cavities with various cavity lengths. The device was fabricated by employing a direct laser patterning that is a less time-consuming, more approachable, and low-cost technique. As switching the state of Sb2S3 between amorphous and crystalline, the multi-color of stepwise pixelated FP cavities can be actively changed. The color variation is due to the profound change in the refractive index of Sb2S3 over the visible spectrum during its phase transition. Moreover, we directly fabricated sub-50 nm nano-grating on ultrathin Sb2S3 laminate via microsphere 800-nm femtosecond laser irradiation in far field. The minimum feature size can be further decreased down to ~45 nm (λ/17) by varying the thickness of Sb2S3 film. Ultrafast switchable Sb2S3 photonic devices can take one step toward the next generation of inkless erasable papers or displays and enable information encryption, camouflaging surfaces, anticounterfeiting, etc. Importantly, our work explores the prospects of rapid and rewritable fabrication of periodic structures with nano-scale resolution and can serve as a guideline for further development of chalcogenide-based photonics components.
tunable color displays Fabry-Pérot cavity resonators color printing chalcogenide materials 
Opto-Electronic Advances
2024, 7(1): 230033
Author Affiliations
Abstract
1 School of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan 430074, China
2 Beijing Institute of Space Mechanics and Electricity, Beijing 100076, China
3 School of Physics and School of Aeronautics and Astronautics, University of Electronic Science and Technology of China, Chengdu 610054, China
4 State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics, Tsinghua University, Beijing 100084, China
Opto-Electronic Advances
2024, 7(1): 220016C
Author Affiliations
Abstract
1 The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry, School of Physics and TEDA Institute of Applied Physics, Nankai University, Tianjin 300071, P. R. China
2 State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, P. R. China
3 Shenzhen Research Institute of Nankai University, Shenzhen, Guangdong, 518083, P. R. China
4 Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan, Shanxi 030006, P. R. China
Collective cell migration is a coordinated movement of multi-cell systems essential for various processes throughout life. The collective motions often occur under spatial restrictions, hallmarked by the collective rotation of epithelial cells confined in circular substrates. Here, we aim to explore how geometric shapes of confinement regulate this collective cell movement. We develop quantitative methods for cell velocity orientation analysis, and find that boundary cells exhibit stronger tangential ordering migration than inner cells in circular pattern. Furthermore, decreased tangential ordering movement capability of collective cells in triangular and square patterns are observed, due to the disturbance of cell motion at unsmooth corners of these patterns. On the other hand, the collective cell rotation is slightly affected by a convex defect of the circular pattern, while almost hindered with a concave defect, also resulting from different smoothness features of their boundaries. Numerical simulations employing cell Potts model well reproduce and extend experimental observations. Together, our results highlight the importance of boundary smoothness in the regulation of collective cell tangential ordering migration.
Collective cell migration spatial restrictions tangential ordering geometric regulation cell Potts model 
Journal of Innovative Optical Health Sciences
2024, 17(2): 2450001
Author Affiliations
Abstract
1 State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, P. R. China
2 Key Laboratory of Biomedical Engineering of Hainan Province, One Health Institute, Hainan University, Haikou 570228, P. R. China
3 Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, P. R. China
4 Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, P. R. China
Monomethyl auristatin E (MMAE) is a derivative of the marine peptide Dolastatin 10, which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical trials. The antibody drug conjugate (ADC) of MMAE is currently used in clinical practice. However, the safety issues of MMAE-based ADC, such as high drug toxicity and poor bioavailability, still exist when using it for anticancer therapy. A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer effects. Herein, PLGA-b-PEG2000 with excellent biocompatibility and slow degradation ability was adopted to construct MMAE-loaded nanoparticles for safe and effective chemotherapy. The sustained release effect and the immunogenic cell death (ICD) effect of PLGA-MMAE nanoparticles were assessed by in vitro experiments. The PLGA-MMAE nanoparticles effectively accumulated in the tumor through the enhanced permeability and retention (EPR) effect, inducing cell apoptosis and causing a certain degree of immune response. The sustained drug release of PLGA-MMAE improved the bioavailability and effectively reduced the toxicity and development of the tumor compared to the effect of free MMAE or ADC. Overall, this study provides a safe and effective chemotherapeutic approach, as well as a simple and effective synthetic process for MMAE-based nanoparticles, improving their therapeutic efficacy and safety.
Monomethyl auristatin E poly (lactic-co-glycolic acid) nanoparticles sustained release chemotherapy immunogenic cell death 
Journal of Innovative Optical Health Sciences
2024, 17(2): 2350024
Author Affiliations
Abstract
1 School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, P. R. China
2 School of Medical Technology, Beijing Institute of Technology, Beijing 100081, P. R. China
3 Department of Laser Medicine, First Medical Center of PLA General Hospital, Beijing 100853, P. R. China
4 Britton Chance Center for Biomedical Photonics – MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P. R. China
5 Precision Laser Medical Diagnosis and Treatment Innovation Unit, Chinese Academy of Medical Sciences, Beijing 100000, P. R. China
Vascular-targeted photodynamic therapy (V-PDT) is an effective treatment for port wine stains (PWS). However, repeated treatment is usually needed to achieve optimal treatment outcomes, possibly due to the limited treatment light penetration depth in the PWS lesion. The optical clearing technique can increase light penetration in depth by reducing light scattering. This study aimed to investigate the V-PDT in combination with an optical clearing agent (OCA) for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber model. Vascular responses were closely monitored with laser speckle contrast imaging (LSCI), optical coherence tomography angiography, and stereo microscope before, during, and after the treatment. We further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin microvasculature. The combination of OCA and V-PDT resulted in significant vascular damage, including vasoconstriction and the reduction of blood flow. Our results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases, including PWS.
Vascular-targeted photodynamic therapy (V-PDT) optical clearing agent (OCA) treatment efficacy enhancement skin-fold window chamber port wine stains 
Journal of Innovative Optical Health Sciences
2024, 17(2): 2350023
Author Affiliations
Abstract
1 School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230041, P. R. China
2 Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu 215163, P. R. China
Light-sheet fluorescence microscopy (LSFM) has been widely used to image the three-dimensional (3D) structures and functions of various millimeter-size bio-specimen such as zebrafish. However, the sample adsorption and scattering cause shading of the light-sheet illumination, preventing the even 3D image of thick samples. Herein, we report a continuous-rotational light-sheet microscope (CR-LSM) that enables simultaneous 3D bright-field and fluorescence imaging. With a high-accuracy rotational stage, CR-LSM records the outline projections and the fluorescent images of the sample at multiple rotation angles. Then, 3D morphology and fluorescent structure were reconstructed with a developed algorithm. Using CR-LSM, zebrafish’s whole-fish contour and blood vessel structures were obtained simultaneously.
Light-sheet microscope zebrafish blood vessels morphology 
Journal of Innovative Optical Health Sciences
2024, 17(2): 2350022

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