激光技术, 2023, 47 (2): 280, 网络出版: 2023-04-12  

基于LED照明的时域全场OCT成像系统设计

Design of time domain full field OCT imaging system based on LED illumination
作者单位
北京信息科技大学 光电测试技术及仪器教育部重点实验室, 北京 100192
摘要
为了进一步降低成本并提高成像的速度与精度, 提出了一种基于发光二极管(LED)照明的全场时域光学相干层析成像技术(OCT)系统。用LED作光源、采用带反馈的闭环四步移相法采集信号, 阐述了其成像原理, 并进行了系统结构研究、理论分析和实验验证。结果表明, 系统的相干长度为23 μm, 轴向分辨率达到了11.8 μm, 横向分辨率为19.8 μm, 单幅图的采集时间为2.15 ms; 与以往的OCT扫描方式相比, 该方法减小了实现成本, 并具有更快的扫描速率以及更高的精度, 有着很大的使用价值。该研究为开发超高速、高精度的低成本OCT系统提供了参考。
Abstract
In order to further reduce the cost and to improve the imaging speed and accuracy, a full field time-domain optical coherence tomography (OCT) system based on light-emitting diode (LED) illumination was proposed. The LED was used as the light source and the closed-loop four-step phase-shifting method with feedback was used to collect signals. Its imaging principle was described, and the system structure was studied, theoretical analysis and experimental verification were carried out. The results show that the coherence length of the system is 23 μm, the axial resolution is 11.8 μm, the lateral resolution is 19.8 μm, and the acquisition time of single image is 2.15 ms, respectively. Compared with the previous OCT scanning methods, the implementation cost is reduced by this method, and the scanning rate and accuracy is respectively faster and higher, which meaning great application value. This research provides a reference for the development of ultra-high speed, high precision and low-cost OCT system.
参考文献

[1] XU J N. Analysis of optical coherence tomography technology and ridge image detection [J].Application of Photoelectric Technology, 2019, 34(1): 41-44 (in Chinese).

[2] XIA S, YANG J Y, CHEN Y X.Observation on image characteristics of ophthalmic coherence tomography in patients with polypoid choroidal vascular disease [J]. Chinese Journal of Fundus Diseases, 2019, 35(4): 385-387 (in Chinese).

[3] NASSIF N A, CENSE B, PARK B H, et al. In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve[J]. Optics Express, 2004, 12(3): 367-376.

[4] ASRANI S, SARUNIC M, SANTIAGO C, et al. Detailed visualization of the anterior segment using fourier-domain optical coherence tomography[J]. Archives of Ophthalmology, 2008, 126(6): 765-771.

[5] SHEN Y, CHEN Z, BAO W, et al. Amplified phase measurement of thin-film thickness by swept-source spectral interferometry [J]. Optics Communications, 2015, 355: 562-566.

[6] ERKKI A, AHMED A, E J G. Online monitoring of printed electro-nics by spectral-domain optical coherence tomography [J]. Scientific Reports, 2013, 3(1): 1562.

[7] HUANG Y X, YAO J Q, LING F R, et al. Terahertz imaging technology based on coherent tomography [J]. Laser and Infrared, 2015, 45(10): 1261-1265 (in Chinese).

[8] YANG H B. Three-dimensional contour measurement system based on optical coherence tomography [D].Guangzhou: Guangdong University of Technology of China, 2019:2-3 (in Chinese).

[9] GAO F.Key technologies research in sweept source optical coherence tomography applied on human eye imaging [D].Chengdu: University of Electronic Science and Technology, 2016:11-12 (in Chinese).

[10] WU J D, ZENG Sh Q, LUO Q M. A high sensitive optical coherence tomography system with light-emitting diode [J]. Opto-Electronic Engineering, 2001, 28(4): 46-49 (in Chinese).

[11] NANDAKUMAR H, SRIVASTAVA S. Low cost open-source oct using undergraduate lab components[M].London, UK: IntechOpen, 2020:75-89.

[12] LUO M T.Non-destructive testing and evaluation of multilayered thin-film structures based on time-domain optical coherence tomography system [D].Fuzhou: Fuzhou University, 2015:4-5 (in Ch-inese).

[13] APELIAN C, HARMS F, THOUVENIN O, et al. Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by interferometric signals temporal analysis [J]. Biomedical Optics Express, 2016, 7(4): 1511-1524.

[14] YANG Q, ZHU L Q, FAN F, et al. Signal retrieval method of en-face optical coherence tomography system [J].Acta Optica Sinica, 2020, 40(7): 0711001 (in Chinese).

[15] ZHANG Sh X, ZHAO Sh, WANG Y Zh, et al. White led beam shaping technology based on free-form surface lens [J]. Laser Techno-logy, 2021, 45(3): 357-361 (in Chinese).

[16] ZHANG Q, XU X F, YUAN H G, et al. Phase-shift extraction and wave reconstruction in four-step phase-shifting interferometry [J].Optoelectronic Engineering, 2011, 38 (8): 139-144 (in Chinese).

[17] WANG L, FU Z R, LIU F P, et al. Holographic information hiding based on the four-step phase shifting method [J]. Journal of Beijing Institute of Printing, 2017, 25(2):30-34 (in Chinese).

[18] CAI Ch Q, HE L F. Phase difference extraction based on four-step phase shifting [J].Journal of South China University of Technology (Natural Science Edition), 2011, 39(9):93-96(in Chinese).

[19] XU Zh N. Research on led based low-coherence phase-shifting digital holographic microscopy and phase-shifting calibration [D].Guangzhou: Jinan University, 2014:14-15 (in Chinese).

[20] MAZLIN V, XIAO P, DALIMIER E, et al. In vivo high resolution human corneal imaging using full-field optical coherence tomography [J]. Biomedical Optics Express, 2018, 9(2): 557-568.

马志明, 王晓玲, 周哲海. 基于LED照明的时域全场OCT成像系统设计[J]. 激光技术, 2023, 47(2): 280. MA Zhiming, WANG Xiaoling, ZHOU Zhehai. Design of time domain full field OCT imaging system based on LED illumination[J]. Laser Technology, 2023, 47(2): 280.

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