激光与光电子学进展, 2024, 61 (1): 0130001, 网络出版: 2024-02-21  

单级虚像相位阵列光谱仪应用于角膜及晶状体二维成像光谱色散率研究(特邀)创刊六十周年特邀

Dispersion Rate of Single-Stage Virtually Imaged Phased Array Spectrometer for Two-Dimensional Imaging of the Cornea and Lens (Invited)
何兴道 1,2,*许锦 1,2刘明轩 1,3史久林 1,2,3,**
作者单位
1 南昌航空大学江西省光电信息科学与技术重点实验室,江西 南昌 330063
2 北京航空航天大学仪器科学与光电工程学院,北京 100191
3 南昌航空大学无损检测技术教育部重点实验室,江西 南昌 330063
摘要
基于单级虚像相位阵列(VIPA)的布里渊散射光谱信号检测技术具有结构简单、光通量高的特点,在透明生物组织弹性快速检测方面具有优势。眼角膜和晶状体是典型的透明组织,但由于单级VIPA光谱仪中布里渊信号易被弹性散射淹没,限制了其信噪比和分辨率的提高,成为临床进一步应用的技术瓶颈。针对这一问题,从理论和实验两方面探究了提升单级VIPA布里渊光谱检测系统性能的方法。利用VIPA的傍轴近似色散模型,理论分析了柱面透镜前准直光束的半径、柱透镜焦距、球面透镜焦距和VIPA倾斜角度对单级VIPA光谱仪色散率的影响。研究结果表明,影响色散率的主要因素是球面透镜焦距、VIPA倾斜角度和探测器分辨率。在实际测试系统中,对一种变焦镜头与高分辨CMOS相机结合的信号接收装置进行有效的参数设计与系统匹配,实现了色速率与散射信号强度的平衡,优化了光谱仪系统各项参数,提升了该检测系统的性能。应用该单级VIPA光谱仪,实现了猪眼角膜和晶状体二维频移成像。该研究结果对于单级VIPA光谱仪在临床诊疗领域的应用具有重要意义。
Abstract
Owing to its simple structure and high light output, Brillouin scattering detection technology based on single-stage virtually imaged phase array (VIPA) spectroscopy has enabled the rapid detection of transparent biological tissue elasticity. The cornea and lens are typical transparent biological tissues. However, elastic scattering can easily overwhelm the weak Brillouin signal in a single-stage VIPA spectrometer, thereby limiting the signal-to-noise ratio and resolution enhancement. This problem has hindered further clinical applications of single-stage VIPA technology. Therefore, this paper investigated theoretical and experimental methods for improving the performance of single-stage VIPA spectroscopy. Theoretically, a paraxial approximate dispersion model of the VIPA was constructed to investigate the variations in the dispersion ratio with the collimated beam radius in front of the cylindrical lens, the focal lengths of the cylindrical and spherical lenses, and the tilt angle of the VIPA. The dispersion rate was primarily affected by the focal length of the spherical lens, the VIPA tilt angle, and the detector resolution. Experimentally, a signal-receiving device combining a zoom lens and high-resolution complementary metal-oxide semiconductor camera was designed and matched to the system. This device balances the dispersion rate and scattering signal intensity, optimizes the parameters of the spectrometer system, and improves the system performance. This paper originally reports the two-dimensional frequency-shift imaging of ex-vivo porcine cornea and lens using a single-stage VIPA spectrometer. The results of this study are expected to advance the field of clinical diagnosis and treatment using single-stage VIPA spectroscopy.

何兴道, 许锦, 刘明轩, 史久林. 单级虚像相位阵列光谱仪应用于角膜及晶状体二维成像光谱色散率研究(特邀)[J]. 激光与光电子学进展, 2024, 61(1): 0130001. Xingdao He, Jin Xu, Mingxuan Liu, Jiulin Shi. Dispersion Rate of Single-Stage Virtually Imaged Phased Array Spectrometer for Two-Dimensional Imaging of the Cornea and Lens (Invited)[J]. Laser & Optoelectronics Progress, 2024, 61(1): 0130001.

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