Houkai Chen 1†Yuquan Zhang 1†Yanmeng Dai 1†Changjun Min 1,3,*[ ... ]Xiaocong Yuan 1,4,*
Author Affiliations
Abstract
1 Nanophotonics Research Center, Shenzhen Key Laboratory of Micro-Scale Optical Information Technology, Shenzhen University, Shenzhen 518060, China
2 Tianjin Union Medical Center, Tianjin 300121, China
3 e-mail: cjmin@szu.edu.cn
4 e-mail: xcyuan@szu.edu.cn
Tip-enhanced Raman scattering (TERS) spectroscopy is a nondestructive and label-free molecular detection approach that provides high sensitivity and nanoscale spatial resolution. Therefore, it has been used in a wide array of applications. We demonstrate a gap-plasmon hybridization facilitated by a bottom-illuminated TERS configuration. The gap-plasmon hybridization effect is first performed with the finite-difference time-domain method to optimize the parameters, and experiments are then conducted to calibrate the performance. The results demonstrate an enhancement factor of 1157 and a spatial resolution of 13.5 nm. The proposed configuration shows great potential in related surface imaging applications in various fields of research.
Photonics Research
2020, 8(2): 02000103
Author Affiliations
Abstract
1 Nanophotonics Research Center, Shenzhen Key Laboratory of Micro-Scale Optical Information Technology, Shenzhen University, Shenzhen 518060, China
2 Tianjin Union Medical Center, Tianjin 300121, China
3 Institute of Modern Optics, Nankai University, Tianjin 300071, China
4 College of Electronic Science and Technology, Shenzhen University, Shenzhen 518060, China
5 e-mail: jingbu@szu.edu.cn
Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface-enhanced Raman scattering (SERS) technique, wide-field Raman imaging is developed with a significant improvement in spatial resolution. As a result of the relatively narrow Raman characteristic peaks, optically encoded SERS nanoparticles can be used to perform multiplexed imaging. The results show excellent superresolution wide-field multiplexed imaging performance. The developed technique has extraordinary potential for applications in biological imaging and other related fields.
Raman microscopy Surface-enhanced Raman scattering Superresolution 
Photonics Research
2018, 6(6): 06000530

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