主要对工程稳定性的问题展开探讨。首先在总结大科学工程项目的干扰稳定性因素基础上，给出了度量稳定性概念，并且提出一种时空耦合的误差分析方法来表征稳定性控制精度。结合柔度曲线方程，分析稳定性设计关键参数和控制方法。一方面，为进行大科学工程项目的结构设计提供一种稳定性精度预估的方法，考虑到环境干扰因素对大规模、大尺度的科学工程稳定性的影响，并结合稳定性设计的关键参数，在限定条件下实现稳定性的设计要求；另一方面，对现存的工程结构，可完成相关的验证计算，根据需要可采取相应的减振方法；根据分析计算结果，提出结构优化设计的方法，为其他大科学工程的稳定性设计提供参考。

The engineering stability in large scientific projects are discussed in general. The concept of stability is presented based on the analysis of factors influencing the stability of large scientific projects， and a time-space coupled error analysis method is proposed to describe the stability control accuracy. With flexibility curve function， the key parameters and controlling methods for stability design are analyzed. The results provide a method for briefly predicting the stability of the structure design of large scientific projects. The requirements for design under given conditions can be determined by considering the influence of surrounding disturbance on large scale scientific projects and the reasonable key parameters for stability design. Meanwhile， carrying out proof calculation will help take necessary vibration absorption measures for the existent projects， and that will also provide meaningful reference to the stability design of other large scientific projects.