中国激光, 2009, 36 (9): 2251, 网络出版: 2009-10-09
激光或单色光引起非视觉细胞信号转导的现象与机理
Phenomena and Mechanism of Laser Irradiation or Monochromatic Light Induced Extraocular Phototransduction
摘要
激光或单色光(LI)对生物系统存在光生物调节作用(PBM)。LI与细胞分子的量子力学相互作用决定了PBM的剂量关系。低强度LI(LIL)(-10 mW/cm2)的PBM主要由状态依赖的视觉外光信号转导所介导。中等强度LI(MIL)(102-103 mW/cm2)的PBM主要由活性氧介导。它们都支持PBM的生物信息模型(biological information model of PBM, BIMP)。细胞的信号转导通路可以分为两类,Gs蛋白介导的通路为通路1,蛋白激酶C和丝裂原活化蛋白激酶等其他信号通路为通路2。目前发现的光信号转导通路几乎都属于通路2,但BIMP预言了通路1的存在。
Abstract
There is the photobiomodulation (PBM) of laser irradiation or monochromatic light (LI) on biosystems. The quantum mechanics of the interaction of LI and cellular molecules determines PBM dosage. The PBM of low intensity LI, -10 mW/cm2, is mainly mediated by state-dependent extraocular phototransduction, but the PBM of moderate intensity LI, 102-103 mW/cm2, is mainly mediated by reactive oxygen species mediated signal transduction, both of which support our biological information model of PBM (BIMP). The signal transduction pathways can be classified as two kinds, pathway 1 mediated by the Gs protein mediated pathways, and pathway 2 mediated by the other pathways such as protein kinase Cs mediated pathways and mitogen-activated protein kinase mediated pathways. Almost all the present pathways found to mediate PBM belong to pathway 2, but pathway 1 mediated PBM has been predicted according to BIMP.
刘承宜, 朱玲, 段锐, 刘颂豪. 激光或单色光引起非视觉细胞信号转导的现象与机理[J]. 中国激光, 2009, 36(9): 2251. Liu Chengyi, Zhu Ling, Duan Rui, Liu Songhao. Phenomena and Mechanism of Laser Irradiation or Monochromatic Light Induced Extraocular Phototransduction[J]. Chinese Journal of Lasers, 2009, 36(9): 2251.