利用光学相干层析成像（OCT）技术监测了活体小鼠光老化皮肤的嫩肤效果。利用强脉冲光（IPL）照射经过紫外线诱导后的光老化皮肤，采用OCT观察该皮肤,得到不同能量密度IPL作用前后的光老化皮肤光衰减系数的变化情况，用来判断光老化皮肤的光热损伤程度及修复过程。结果表明，IPL能对光老化皮肤进行有效的嫩肤治疗；OCT是活体监测生物组织胶原修复情况的有力工具。

The optical coherence tomography(OCT) technology is used to monitor the treatment of photoaged mouse skin, which is irradiated by intense plused light(IPL). A photoaged mouse skin irradiated by ultraviolet, is treated by IPL. The OCT technology is used to observe the process of the collagen remodeling in dermis. The change of optical characteristic parameter such as attenuation coefficient during the skin rejunvenation is gotten, and the magnitude of optical-thermal damage based on the changes of optical parameter is estimated. The results indicate that IPL can be used for symptoms of photoaged skin as a nonablative method, and OCT has potential as a method for characterization of collagen remodling in vivo in clinic.