Chinese Optics Letters, 2010, 8 (10): 964, Published Online: Oct. 19, 2010
A new visual investigation into nanogold-based genechip assay by atomic force and scanning tunneling microscope Download: 862次
纳米金 银 基因芯片 原子力显微镜 扫描隧道显微镜 110.0180 Microscopy 110.2970 Image detection systems 180.5810 Scanning microscopy 040.5160 Photodetectors
Abstract
Conformations of surface atoms in various stages of nanogold-based genechip testing are scanned by the atomic force and scanning tunneling microscope. We intuitively observe the process and differences in probe combination, nucleic acid hybridization, and silver staining, which might be useful to validate the assay method of genechip. We hope to use this technology to make the other invisible chemical or biochemical reaction become visible and convincible in the future.
Dayong Gu, Weidong Xie, Zhen Li, Weiping Lu, Yuanguo Zhou, Minghui Ji. A new visual investigation into nanogold-based genechip assay by atomic force and scanning tunneling microscope[J]. Chinese Optics Letters, 2010, 8(10): 964.