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Spectral domain optical coherence tomography with sub-micrometer sensitivity for measurement of central corneal thickness

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Abstract

We demonstrated a method for measurement of central corneal thickness (CCT) with a sub-micrometer sensitivity using a spectral domain optical coherence tomography system without needing a super broad bandwidth light source. By combining the frequency and phase components of Fourier transform, the method is capable of measurement of a large dynamic range with a high sensitivity. Absolute phases are retrieved by comparing the correlations between the detected and simulated interference fringes. The phase unwrapping ability of the present method was quantitatively tested by measuring the displacement of a piezo linear stage. The human CCTs of six volunteers were measured to verify its clinical application. It provides a potential tool for clinical diagnosis and research applications in ophthalmology.

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DOI:10.3788/col201917.041701

所属栏目:Medical optics and biotechnology

基金项目:This research was supported in part by the National Natural Science Foundation of China (NSFC) (Nos. 61275214, 31170956, and 61771119), the Natural Science Foundation of Hebei Province, China (Nos. A2015501065 and H2015501133), and the Fundamental Research Funds for Central Universities (No. N172304034).

收稿日期:2018-10-31

录用日期:2019-01-10

网络出版日期:2019-04-01

作者单位    点击查看

Lida Zhu:School of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China
Yi Wang:School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China
Yi Yuan:School of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China
Hongxian Zhou:Experiment Education Center, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China
Yuqian Zhao:School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China
Zhenhe Ma:School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China

联系人作者:Yi Wang(wangyi@neuq.edu.cn)

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引用该论文

Lida Zhu, Yi Wang, Yi Yuan, Hongxian Zhou, Yuqian Zhao, Zhenhe Ma, "Spectral domain optical coherence tomography with sub-micrometer sensitivity for measurement of central corneal thickness," Chinese Optics Letters 17(4), 041701 (2019)

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