基于计算机模拟的葡萄酒色斑激光热疗中喷射冷却机理的数值分析

制冷剂喷射冷却(CSC)是采用激光热疗法治疗葡萄酒色斑(PWS)的重要辅助手段。为了揭示CSC在激光热疗中的冷却保护机理, 采用计算机数值计算的方法定量分析带有CSC的PWS激光热疗过程。结果表明, 采用计算机数值解法离散微分方程, 很好地模拟了带有CSC的PWS激光热疗过程。CSC可有效保护表皮层免受热损伤, 而且可提高激光热疗过程中的许用激光能量密度, 有助于增加疗效; 皮肤表面温度随着传热系数的增加而降低, 但降低的幅度随传热系数的增大而不断减小; 提高组织的初始温度有助于提高疗效, 但有可能带来热损伤危险, 应同时适当延长制冷剂喷射时间以避免发生热损伤。

Abstract

Cryogen spray cooling (CSC) was proved to be an effective method to avoid the hyper-thermal injury in epidermal layer during the laser treatment of port wine stain (PWS). A numerical analysis was performed to show the thermal history during the CSC process. The analysis reveals that CSC does not only reduce the surface temperature and protect the skin surface from burning but also makes a high energy density possible to improve the clinic outcomes. The impact of the heat transfer coefficient and the initial tissue temperature on the cooling effect of CSC was also examined. We find that the surface temperature decreases as the heat transfer coefficient increases and a high initial temperature improves the clinical outcomes by increasing the final temperature in the PWS layer. However, a high initial temperature might increase the possibility of heat injuries, which should be avoided by extending the cryogen spraying time.

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李艳, 李葆华. 基于计算机模拟的葡萄酒色斑激光热疗中喷射冷却机理的数值分析[J]. 激光与光电子学进展, 2017, 54(2): 021701. Li Yan, Li Baohua. Computer Simulation Based Numerical Analysis of Cryogen Spray Cooling Mechanism in Laser Treatment of Port Wine Stain[J]. Laser & Optoelectronics Progress, 2017, 54(2): 021701.

基于计算机模拟的葡萄酒色斑激光热疗中喷射冷却机理的数值分析

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