离体生物组织激光焊接特性实验研究

为了获得激光焊接工艺参数对离体生物组织融合效果的影响规律, 设计实验探究了激光功率、激光扫描方式等参数对离体皮肤切口融合形貌及抗张强度的影响, 并对工艺参数进行了优化。结果表明, 采用小功率长时间工艺规范焊接离体皮肤组织, 组织切口融合效果较好、抗张强度较高, 并且可以减小不可逆的热损伤; 采用分段扫描焊接方式, 可以加强切口附近成分的活性, 减小切口热损伤。在此基础上, 采用优化的工艺参数进行可靠性实验, 并对切口抗张强度进行了测试。结果表明, 在该工艺条件下, 组织切口可实现全层融合, 并且无烧损、碳化等缺陷, 与连续激光焊接工艺相比, 焊接时间可减少30%~40%, 焊后组织切口抗张强度可达0.38 MPa, 满足强度要求。

Abstract

To find out the role of laser parameters on in-vitro tissue bonding, experiments are designed to study the effect of laser parameters, such as power and scanning mode, on the appearance and tensile strength of in-vitro skin tissue incision, and then the process parameters are optimized. Results show that the appearance and tensile strength of tissue incision is better and greater when we use low laser power with long welding time, and also the irreversible thermal damage decreases. Using interval laser scanning increases the bioactivity closed to the incision and decreases the thermal damage. Experiments are performed to verify the reliability and stability of the optimized parameters, and the tensile strength of incision is tested. Results show that the bonding along the depth of tissue can be realized and no carbide or burning occurs. Compared with that of the continuous laser welding process, the welding time is decreased by 30%-40%, and the tensile strength of incision is 0.38 MPa, which can meet the requirement.

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黄俊, 李聪, 王克鸿, 李乐乐. 离体生物组织激光焊接特性实验研究[J]. 中国激光, 2017, 44(4): 0407001. Huang Jun, Li Cong, Wang Kehong, Li Lele. Laser Welding Characteristics of Biological Tissues in vitro[J]. Chinese Journal of Lasers, 2017, 44(4): 0407001.

离体生物组织激光焊接特性实验研究

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