激光与光电子学进展, 2021, 58 (4): 0400001, 网络出版: 2021-02-01
多光谱成像技术及其在生物医学中的应用 
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Multispectral Imaging Technology and Its Applications in Biomedicine
图 & 表
图 1. 基于不同光谱分离元件的MSI系统[19]。(a)轮转滤光片;(b)液晶可调谐滤光片;(c)平面复眼成像系统;(d)多层曲面复眼MSI系统
Fig. 1. MSI systems based on different spectral separation elements[19]. (a) Rotating filter; (b) liquid crystal tunable filter; (c) planar compound eye imaging system; (d) multi-layer curved compound eye MSI system
图 3. 多光谱显微成像系统。(a)多波段荧光显微镜;(b)基于光纤的多光谱显微内窥镜;(c)多光谱光声层析成像系统
Fig. 3. Multispectral microscopic imaging systems. (a) Multi-wavelength fluorescent microscopy; (b) fiber-based multispectral endomicroscopy; (c) multispectral optoacoustic tomography
图 4. 多层复合超材料用于多光谱消色差成像[37]。(a)多层复合结构示意图;(b)白光照明下的光谱特征及红光焦点强度分布;(c)三个特征峰焦点
Fig. 4. Multilayer composite metasurfaces used for multispectral achromatic imaging[37]. (a) Diagram of multilayer composite structure; (b) spectrum taken under white light illumination and distribution of focal spot of red light (650 nm); (c) foci of three characteristic peaks
图 5. MSI技术用于皮肤组织检测。(a)采用近红外波段对皮肤切片进行多光谱成像,并区分正常组织与病变组织[51];(b)多光谱光声成像在体检测皮肤的黑色素和血液中氧合水平[52]
Fig. 5. MSI technology used for skin tissue detection. (a) Multispectral imaging for skin slice via NIR MSI to distinguish healthy tissues from diseased tissues[51]; (b) MSOT for in vivo detection of skin melanin and blood oxygenation level[52]
图 6. 多光谱光声层析成像技术对乳腺癌肿瘤边缘的评估[59]。 (a)切除组织的超声图像,其中虚线区域为肿瘤组织;(b)光声图像标示脂质和脱氧血红蛋白;(c)图6 (b)中方框区域放大图,显示脱氧血红蛋白信号可以用于判别肿瘤边缘
Fig. 6. Assessment of breast tumor margins via MSOT[59]. (a) Ultrasound image of the excised specimen. Dashed area is tumor tissue; (b) multispectral optoacoustic image shows lipids and deoxyhemoglobin; (c) enlarged view shows that deoxyhemoglobin signal can be used to identify tumor margin
图 7. 多光谱生物特征识别。(a)虹膜血管和纹理的多光谱特征获取及分析[66];(b)四元数模型用于多光谱掌纹信息识别[74];(c)面部多光谱图像与特征分层融合技术,用于实现脸部识别[83]
Fig. 7. Multispectral biometric feature recognition. (a) Extract and analyze multispectral characteristics of conjunctival vessels and iris textures[66]; (b) quaternion model for multispectral palmprint information recognition[74]; (c) hierarchical fusion of multi-spectral images and feature of face for face recognition[83]
陈键伟, 龚辉, 袁菁. 多光谱成像技术及其在生物医学中的应用[J]. 激光与光电子学进展, 2021, 58(4): 0400001. Jianwei Chen, Hui Gong, Jing Yuan. Multispectral Imaging Technology and Its Applications in Biomedicine[J]. Laser & Optoelectronics Progress, 2021, 58(4): 0400001.
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