对称型长程表面等离子体共振分析系统

表面等离子体共振(SPR)技术中的长程SPR技术的实际应用受其特殊的膜层匹配条件(待测物和第一层缓冲层折射率需相近)限制而很难扩展。为了解决这一问题，本文提出了一种对称型长程SPR (LRSPR)技术来提高传统LRSPR技术的适用性。设计了一种"缓冲介质层+金属膜+缓冲介质层"的对称型膜层结构，用于打破传统LRSPR折射率匹配条件的制约，并进一步提高电磁场穿透深度和共振峰深度。理论模拟分析了对称型膜层结构，并且自行搭建了基于LED光源的角度谱SPR检测系统。利用该系统进行了不同糖浓度溶液下的折射率分辨率实验，并对数据处理的算法进行了优化。实验测得系统的折射率分辨率达到6.1×10-7 RIU，灵敏度可达1.22×105 pixel/RIU，并且在一定折射率测量范围内具有较好的线性度。

Abstract

Applications of the Long Range Surface Plasmon Resonance (LRSPR) technology from the SPRs are hard to be popularized because of its special film matching conditions, namely, the refractive index of the buffer layer must be similar to that of the tested sample. To improve the applicability of the traditional LRSPR technology, a symmetric LRSPR technology was proposed. A symmetric film structure ( buffer dielectric layer + metal film + buffer dielectric layer) was designed to break the limitations of the matching conditions and to further improve the penetration depth of electromagnetic field and the resonance peak depth. The symmetric film structure was analyzed theoretically, and an angular spectrum SPR detection system was built by using a Light Emitting Diode(LED) as the light source. The measuring system was used to measure the refractivity resolution of different glucose solutions, and the algorithm proposed was optimized. The results show that the refractivity resolution of the system can reach 6.1×10-7 RIU, the sensitivity is 1.22×105 pixel/RIU and a better linearity is obtained in a refractivity measuring range.

参考文献

[1] 齐攀，李莹，冯明创，等. 用于阵列样品检测的扫描式表面等离子体共振生物传感器［J］. 光学精密工程, 2012， 20(11): 2365-2372.

QI P, LI Y, FENG M CH, et al.. Scanning surface plasmon resonance biosensor for array sample detection［J］. Opt. Precision Eng., 2012， 20(11): 2365-2372.(in Chinese)

[2] HOMOLA J.Surface plasmon resonance sensors for detection of chemical and biological species ［J］.Chemical Reviews,2008,108(2): 462.

[3] GORDON I J G, ERNST S. Surface plasmons as a probe of the electrochemical interface［J］. Surface Science, 1980, 101(1): 499-506.

[4] NYLANDER C, LIEDBERG B, LIND T. Gas detection by means of surface plasmon resonance［J］. Sensors and Actuators, 1983, 3: 79-88.

[5] SARID D.Long-range surface-plasma waves on very thin metal films ［J］.Physical Review Letters,1981,47(26): 1927-1930.

[6] RAETHER H,KRETSCHMANN E.Radiative decay of non radiative surface plasmons excited by light ［J］.Z.Naturforsch.,1968,23: 2135-2136.

[7] BAKER L R. Electromagnetic surface modes［J］. Journal of Modern Optics, 1983, 30(3): 257-257.

[8] RAETHER H. Surface Plasmons on Smooth and Rough Surfaces and on Gratings［M］. Springer Tracts in Modern Physics, 1988: 111.

[9] HOMOLA J. On the sensitivity of surface plasmon resonance sensors with spectral interrogation［J］. Sensors and Actuators B: Chemical, 1997， 41(1): 207-211.

[10] 郝鹏，吴一辉.基于噪声分析的波长表面等离子体共振分析仪的数据处理［J］. 光学精密工程, 2009，17(9): 2159-2164.

HAO P， WU Y H. Data process of spectroscopic surface plasmon resonance analyzer based on noise analysis［J］. Opt. Precision Eng., 2009，17(9): 2159-2164.(in Chinese)

[11] MAIER J S. Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissues in the near infrared ［J］. Optics Letters, 1994， 19(24): 2062-2064.

[12] LIU Z Y, YANG L, LIU L, et al.. Parallel-scan based microarray imager capable of simultaneous surface plasmon resonance and hyperspectral fluorescence imaging ［J］. Biosensors & Bioelectronics, 2011, 30: 180-187.

[13] LIU L, HE Y H, ZHANG Y, et al.. Parallel scan spectral surface plasmon resonance imaging［J］. Applied Optics, 2008, 47(30): 5616-5621.

黄强, 王敏, 李昂, 韩西达, 何永红. 对称型长程表面等离子体共振分析系统[J]. 光学精密工程, 2014, 22(1): 44. HUANG Qiang, WANG Min, LI Ang, HAN Xi-da, HE Yong-hong. Symmetrical long range surface plasmon resonance sensing system[J]. Optics and Precision Engineering, 2014, 22(1): 44.

对称型长程表面等离子体共振分析系统

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