5-HT<sub>3</sub>受体拮抗剂药物甲磺酸多拉司琼的分子光谱研究

Dolasetron mesylate is a 5-HT3 receptor antagonist which is used on chemotherapy for the prophylaxis of nausea and vomiting. In this paper, the molecular vibration of dolasetron mesylate was detected and measured by FTIR and Raman spectroscopic analysis, the difference between Infrared and Raman characteristic group frequencies of dolasetron mesylate was discussed, and the molecule vibration was assigned and identified to associate characteristic frequencies with its characteristic structure. These experiment results provide more important information for pharmaceutical synthesis and quality control.

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陈晓红, 张倩芝, 张卫红, 陈建. 5-HT₃受体拮抗剂药物甲磺酸多拉司琼的分子光谱研究[J]. 光散射学报, 2008, 20(1): 86. CHEN Xiao-hong, ZHANG Qian-zhi, ZHANG Wei-hong, CHEN Jian. Spectroscopic Analysis on 5-HT₃ Receptor Antagonist Dolasetron Mesylate[J]. The Journal of Light Scattering, 2008, 20(1): 86.

5-HT₃受体拮抗剂药物甲磺酸多拉司琼的分子光谱研究

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