红外与激光工程, 2016, 45 (5): 0525001, 网络出版: 2016-06-12   

太赫兹波对肾癌组织的光谱检测

Terahertz spectral detection in human renal tissue
李晗 1,2余晨 2
作者单位
1 上海市第一康复医院, 上海 200090
2 同济大学附属同济医院, 上海 200065
摘要
利用太赫兹光谱技术, 对人肾癌组织进行检测, 分别比较了肿瘤组织和肿瘤旁正常组织对太赫兹波的响应。通过对新鲜含水和经冷冻真空脱水组织的测量分析, 分别获得了不同样品在0.2~1.2 THz波段的吸收系数和折射率。结果显示, 生物组织中含水量对太赫兹波吸收信号强度有很大的影响。同时, 不同组织的细胞结构和成分也是影响太赫兹信号强度的重要因素。比如癌细胞和正常细胞的结构的不同, 因此对太赫兹电磁波的吸收以及它们在太赫兹波段的折射率都有显著的不同。结果显示太赫兹光谱技术在生物组织检测和临床医学如肿瘤疾病诊断方面具有广阔的应用前景。
Abstract
In this paper, terahertz spectroscopy technique was used for the investigation of human renal cancer by comparing the response of tumor tissue and normal tissue adjacent to tumor. Based on the measurement and analysis of fresh tissue and lyophilized tissue respectively, the absorption coefficient and refractive index from 0.2 THz to 1.2 THz were obtained. The result shows that water content of biological tissue has great influence on terahertz wave absorption signal amplitude. Meanwhile, difference of cell structure and composition also affect the transmission of terahertz signal. For example, as the different structure and composition of the cancer and normal cell, the absorption coefficient and refractive index of these tissues are completely different. The result indicates that terahertz spectroscopy technique is an important technology and has a broad prospect of application in biological tissue investigation and clinical medicine such as tumor disease diagnosis.
参考文献

[1] Brun M A, Formanek F, Yasuda A, et al. Terahertz imaging applied to cancer diagnosis[J]. Physics in Medicine and Biology, 2010, 55(16): 4615.

[2] 何明霞, 陈涛, 杨吉龙, 等. 太赫兹成像技术在肿瘤诊断方面的应用[J]. 肿瘤, 2012, 32(12): 1039-1042.

    He Mingxia, Chen Tao, Yang Jilong, et al. The application of terahertz imaging in tumor diagnosis[J]. TUMOR, 2012, 32(12): 1039-1042. (in Chinese)

[3] Wallace V P, Fitzgerald A J, Pickwell E, et al. Terahertz pulsed spectroscopy of human basal cell carcinoma[J]. Applied Spectroscopy, 2006, 60(10): 1127-1133.

[4] Taylor Z D, Singh R S, Culjat M O, et al. Reflective terahertz imaging of porcine skin burns[J]. Optics Letters, 2008, 33(11): 1258-1260.

[5] Pickwell-MacPherson E, Fitzgerald A J, Wallace V P. Breast cancer tissue diagnosis at terahertz frequencies[C]//SPIE BiOS. International Society for Optics and Photonics, 2012: 82210M.

[6] Hassan A M, Hufnagle D C, El-Shenawee M, et al. Terahertz imaging for margin assessment of breast cancer tumors[C]//Microwave Symposium Digest(MTT), IEEE MTT-S International, 2012: 1-3.

[7] Enatsu T, Kitahara H, Takano K, et al. Terahertz spectroscopic imaging of paraffin-embedded liver cancer samples[C]//Infrared and Millimeter Waves, 2007 and the 2007 15th International Conference on Terahertz Electronics. IRMMW-THz. Joint 32nd International Conference on IEEE, 2007: 557-558.

[8] Wahaia F, Valusis G, Bernardo L M, et al. Detection of colon cancer by terahertz techniques[J]. Journal of Molecular Structure, 2011, 1006(1): 77-82.

[9] Sim Y C, Ahn K M, Park J Y, et al. Temperature-dependent terahertz imaging of excised oral malignant melanoma[J]. Biomedical and Health Informatics, IEEE Journal of, 2013, 17(4): 779-784.

[10] He M, Azad A K, Ye S, et al. Far-infrared signature of animal tissues characterized by terahertz time-domain spectroscopy[J]. Optics Communications, 2006, 259(1): 389-392.

[11] Oh S J, Kim S H, Ji Y B, et al. Study of freshly excised brain tissues using terahertz imaging[J]. Biomedical Optics Express, 2014, 5(8): 2837-2842.

[12] Chen H, Chen T H, Tseng T F, et al. High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model[J]. Optics Express, 2011, 19(22): 21552-21562.

[13] Xu J, Plaxco K W, Allen S J. Absorption spectra of liquid water and aqueous buffers between 0.3 and 3.72 THz[J]. Journal of Chemical Physics, 2006, 124(3): 36101-36101.

[14] Ashworth P C, Pickwell-MacPherson E, Pinder S E, et al. Terahertz spectroscopy of breast tumors[C]//Infrared and Millimeter Waves, 2007 and the 2007 15th International Conference on Terahertz Electronics, Joint 32nd International Conference on, IEEE, 2007: 603-605.

[15] Wahaia F, Kasalynas I, Seliuta D, et al. Study of gastric cancer samples using terahertz techniques[C]//Second International Conference on Applications of Optics and Photonics. International Society for Optics and Photonics, 2014: 92864H.

[16] Hou D, Li X, Cai J, et al. Terahertz spectroscopic investigation of human gastric normal and tumor tissues[J]. Physics in Medicine and Biology, 2014, 59(18): 5423.

[17] Kindt J T, Schmuttenmaer C A. Far-infrared dielectric properties of polar liquids probed by femtosecond terahertz pulse spectroscopy[J]. The Journal of Physical Chemistry, 1996, 100(24): 10373-10379.

[18] Stanley H E. Liquid water: A very complex fluid[J]. Pramana, 1999, 53(1): 53-83.

[19] Bruehlmeier M, Roelcke U, Bl 覿uenstein P, et al. Measurement of the extracellular space in brain tumors using 76Br-bromide and PET[J]. Journal of Nuclear Medicine, 2003, 44(8): 1210-1218.

[20] Pickwell E, Cole B E, Fitzgerald A J, et al. Simulation of terahertz pulse propagation in biological systems[J]. Applied Physics Letters, 2004, 84(12): 2190-2192.

[21] Suen J Y, Tewari P, Taylor Z D, et al. Towards medical terahertz sensing of skin hydration[J]. Stud Health Technol Inform, 2009, 142: 364-368.

[22] Woodward R M, Wallace V P, Arnone D D, et al. Terahertz pulsed imaging of skin cancer in the time and frequency domain[J]. Journal of Biological Physics, 2003, 29(2-3): 257-259.

[23] 杨航, 赵红卫, 张建兵, 等. 生物组织脱水过程的太赫兹时域光谱[J]. 红外与毫米波学报, 2014, 33(3): 263-267.

    Yang Hang, Zhao Hongwei, Zhang Jianbing, et al. The dehydration processes of biological tissues investigated by terahertz time-domain spectroscopy[J]. J Infrared Millim Waves, 2014, 33(3): 263-267. (in Chinese)

[24] Ashworth P C, Pickwell-MacPherson E, Provenzano E, et al. Terahertz pulsed spectroscopy of freshly excised human breast cancer[J]. Optics Express, 2009, 17(15): 12444-12454.

[25] 来建成, 张颖颖, 李振华, 等. 生物组织折射率的概念与测量方法评述[J]. 激光生物学报, 2009, 18(2): 133-137.

    Lai Jiancheng, Zhang Yingying, Li Zhenhua, et al. A review of the measurement and concept of refractive index of biological tissues[J]. Acta Laser Biology Sinica, 2009, 18(2): 133-137.(in Chinese)

[26] Backman V, Wallace M B, Perelman L T, et al. Detection of preinvasive cancer cells[J]. Nature, 2000, 406(6791): 35-36.

[27] Pickwell E. Biological applications of terahertz pulsed imaging and spectroscopy[D]. Cambridge: University of Cambridge, 2005.

[28] Wahaia F, Valusis G, Bernardo L M, et al. Detection of colon cancer by terahertz techniques[J]. Journal of Molecular Structure, 2011, 1006(1): 77-82.

[29] Knab J R, Chen J Y, He Y, et al. Terahertz measurements of protein relaxational dynamics[J]. Proceedings of the IEEE, 2007, 95(8): 1605-1610.

[30] Zhang W, Brown E R, Rahman M, et al. Observation of terahertz absorption signatures in microliter DNA solutions[J]. Applied Physics Letters, 2013, 102(2): 023701.

[31] 王晓宇, 袁群. 胃肠镜下常见病形态学诊断与病理[M].第一版. 北京: 人民军医出版社, 2008: 157.

[32] Zaytsev K I, Kudrin K G, Koroleva S A, et al. Medical diagnostics using terahertz pulsed spectroscopy[J]. Journal of Physics: Conference Series, 2014, 486(1): 012014.

李晗, 余晨. 太赫兹波对肾癌组织的光谱检测[J]. 红外与激光工程, 2016, 45(5): 0525001. Li Han, Yu Chen. Terahertz spectral detection in human renal tissue[J]. Infrared and Laser Engineering, 2016, 45(5): 0525001.

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