中国激光, 2020, 47 (2): 0207032, 网络出版: 2020-02-21
基于多角度光声介观成像方法的小动物肿瘤特异性成像 下载: 1115次特邀研究论文
Tumor-Specific Imaging of Small Animals Based on Multi-Angle Optoacoustic Mesoscopy Imaging Method
图 & 表
图 2. 基于球聚焦超声探测器的离焦测量模式
Fig. 2. Out-of-focus measurement mode based on sphere-focused ultrasonic detector
图 3. 仿体实验结果。(a)仿体实物图;(b)传统反投影方法的重建结果;(c)结合虚拟点技术的反投影重建结果
Fig. 3. Results of phantom experiment. (a) Photograph of phantom; (b) reconstructed result by traditional back-projection algorithm; (c) reconstructed result by modified back-projection algorithm combined with virtual point technique
图 4. 所选的3个微球的x轴和y轴剖线图。(a)(d)微球1;(b)(e)微球2;(c)(f)微球3
Fig. 4. Profiles of three microspheres along x and y directions. (a)(d) Microsphere 1; (b)(e) microsphere 2; (c)(f) microsphere 3
图 6. 小鼠肿瘤实验结果。(a)~(f)胰腺癌肿瘤的OPAM成像结果;(g)~(l)肝癌肿瘤的OPAM成像结果
Fig. 6. Experimental results of mouse tumors. (a)--(f) OPAM imaging results of pancreas tumors; (g)--(l) OPAM imaging results of liver tumors
图 7. 胰腺癌肿瘤和肝癌肿瘤的4个指标箱形图,采用双样本t检验方法计算P值,*为P<0.05,**为P<0.01。(a) GASM;(b) GENT;(c) GCON;(d) GCORR
Fig. 7. Box-and-whisker plots of four parameters for pancreas and liver tumors, where P values are calculated by two-sample t-test, *represents P<0.05, and **represents P<0.01. (a) GASM; (b) GENT; (c) GCON; (d) GCORR
表 1三个微球的FWHM值
Table1. FWHM values of three microspheres
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路彤, 高峰, 宋少泽, 陈婷婷, 苗士超, 李娇. 基于多角度光声介观成像方法的小动物肿瘤特异性成像[J]. 中国激光, 2020, 47(2): 0207032. Lu Tong, Gao Feng, Song Shaoze, Chen Tingting, Miao Shichao, Li Jiao. Tumor-Specific Imaging of Small Animals Based on Multi-Angle Optoacoustic Mesoscopy Imaging Method[J]. Chinese Journal of Lasers, 2020, 47(2): 0207032.