生物组织中强度调制的连续激光激发的光声信号影响因素研究

分析了强度调制的连续激光激发的光声信号形成过程以及调制脉宽对光声信号强度的影响，发现随着调制方波脉宽的增加，生物组织吸收的光功率增加，光声信号幅值增加。研究了调制脉宽对光声成像技术轴向分辨率的影响，发现随着调制方波脉宽宽度的增加，光声信号的脉宽增加，其轴向分辨率变差。在理论研究的基础上进行了实验验证，通过方波调制的激光二极管的出射激光激发生物组织获取声信号。在激光二极管出射光功率提高受限的条件下，通过增加作用在生物组织上的光功率密度获取高分辨率、高信噪比的光声图像。对强度调制连续激光激发的光声成像技术的研究能够为光声成像技术提供一种低成本、便携式的设备，为进一步研究提供参考。

Abstract

The forming process of the photoacoustic signal excited by the intensity-modulated continuous-wave laser and the effects of modulation pulse width on photoacoustic signal are researched. It is shown that the power absorbed by the biological tissue increases with the increase of the width of the modulated rectangular pulse and the amplitude of the photoacoustic signal. The effects on the axial resolution of the photoacoustic signal excited by the modulated rectangular pulse are also researched. It is shown that the width of the photoacoustic signal increases with the increase of the width of the modulated rectangular pulse, and the axial resolution of the photoacoustic imaging becomes worse. The modulated rectangular pulse of the continuous-wave laser (laser diode) is used to induce the acoustic signal. The laser power density is raised to obtain photoacoustic imaging with higher signal-to-noise ratio (SNR) and resolution when it is hard to raise the laser power. The research on the influential factor of photoacoustic signal excited by intensity-modulated continuous-wave laser in biological tissue can be used to provide a portable and lower cost instrument.

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张雷洪, 马秀华. 生物组织中强度调制的连续激光激发的光声信号影响因素研究[J]. 中国激光, 2011, 38(11): 1104002. Zhang Leihong, Ma Xiuhua. Study on Influential Factor of Photoacoustic Signal Excited by Intensity-Modulated Continuous-Wave Laser in Biological Tissue[J]. Chinese Journal of Lasers, 2011, 38(11): 1104002.

生物组织中强度调制的连续激光激发的光声信号影响因素研究

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