压缩倾角薄层光学层析成像系统

首先研究了LOT中光线倾斜角度对光在组织体内分布的影响, 在此基础上设计并完成了压缩倾角薄层光学层析成像(cdaLOT)系统, 提出了矫正扫描振镜枕型畸变的新方法, 并发展了基于虚拟源-扩散近似技术和GPU的LOT快速图像重建算法.光路模拟结果表明, cdaLOT系统可使入射主光线倾角减小为传统LOT系统的1/2.cdaLOT系统将测量值与蒙特卡洛模拟结果的相对误差由传统系统的38%降低为18%, 从而缓解了实际测量方式和正向数学模型的不匹配性.仿体成像实验表明: 重建异质体的吸收系数、位置和形状与真实情况基本相符.

Abstract

The influence of the dip angle on light distribution inside tissue was investigated. Based on the investigation, a LOT system with condensed dip-angle (cdaLOT) over the whole detection range was developed. A new method for correcting the deflection-angle of galvanometer mirrors was also proposed. A fast image reconstruction algorithm for LOT was also developed based on the virtual-source diffusion approximation and GPU. Light path simulation showed that the developed cdaLOT system decreased the dip angle of the incident light to 1/2 of that of the traditional LOT system. The relative deviation of the measured data to MC results was about 18% for cdaLOT while that for traditional LOT was as large as 38%. Reconstructed images showed that the reconstructed absorption coefficient, and the position and shape of the inhomogeneity coincided with the real target.

参考文献

[1] Hillman E. and Burgess S. Submillimeter resolution 3D optical imaging of living tissue using laminar optical tomography [J]. Laser & Photonics Reviews, 2009, 3(12):159-17.

[2] Hillman E., Boas D. A., Dale A. Laminar optical tomography: demonstration of millimeterscale depthresolved imaging in turbid media [J]. Optics Letters, 2004, 29(14):1650-1652.

[3] Burgess S. A., Bouchard M. B., Yuan B., et al. Simultaneous multiwavelength laminar optical tomography [J]. Optics Letters, 2008, 33(22):2710-2712.

[4] Burgess S. A., Ratner D., Chen B. R., et al. Fiberoptic and articulating arm implementations of laminar optical tomography for clinical applications [J]. Biomedical Optics Express, 2010, 1(3):780-790.

[5] Yuan S., Li Q., Jiang J., et al. Threedimensional coregistered optical coherence tomography and linescanning fluorescence laminar optical tomography [J]. Optics Letters, 2009, 34(11):1615-1617.

[6] Yuan B., Burgess S. A., Iranmahbood A., A system for highresolution depthresolved optical imaging of fluorescence and absorption contrast [J]. Review of Scientific Instruments, 2009, 80(4):43706.

[7] Jia M Y, Chen X Y, Zhao H J, et al., Virtualsource diffusion approximation for enhanced nearfield modeling of photonmigration in lowalbedo medium [J], Optics Express, 2015, 23(2):1337-1352.

[8] Jia M Y, Wang S, Chen X Y, et al., Parameterized source term in the diffusion approximation for enhanced nearfield modeling of collimated light, 2016 [C], San Diego, CA, USA: SPIE BiOS. International Society for Optics and Photonics, 2016: 97061F-97061F-11.

[9] YI Xi, WU LinHui., WANG Xin. et al. A combined diffuse fluorescence and opotical tomography of steadystate photoncounting mode for breast tumor diagnosis [J]. J. Infrared Millim. Waves (易茜，武林会，王欣, 等.一种基于稳态光子计数模式的面向乳腺扩散荧光光学联合层析成像方法. 红外与毫米波学报), 2014, 33(3): 318-326.

[10] Niu H., Tian F., Lin Z., et al. Development of a compensation algorithm for accurate depth localization in diffuse optical tomography [J], Optics Letters, 2010, 35(3):429-431.

[11] Boas D. A., Pitris C., Ramanujam N. Handbook of Biomedical Optics[M]. Taylor and Francis, 2010.

赵会娟, 贾梦宇, 秦转萍, 王爽, 陈雪影, 李娇, 张林, 高峰. 压缩倾角薄层光学层析成像系统[J]. 红外与毫米波学报, 2016, 35(6): 688. ZHAO Hui-Juan, JIA Meng-Yu, QIN Zhuan-Ping, WANG Shuang, CHEN Xue-Ying, LI Jiao, ZHANG Lin, GAO Feng. Laminar optical tomography system with condensed dip-angle[J]. Journal of Infrared and Millimeter Waves, 2016, 35(6): 688.

压缩倾角薄层光学层析成像系统

关于本站 Cookie 的使用提示

全站搜索

压缩倾角薄层光学层析成像系统

相关论文

相关资讯

关于本站 Cookie 的使用提示

全站搜索