Determining particle size distribution and refractive index in a two-layer tissue phantom by linearly polarized light

Yong Deng; Qiang Lu; Qingming Luo

Chinese Optics Letters, 2006, 4 (1): 0145, Published Online: Jun. 6, 2006

Determining particle size distribution and refractive index in a two-layer tissue phantom by linearly polarized light Download： 670次

论文大纲

Yong Deng Qiang Lu ^*Qingming Luo

Author Affiliations

Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074

170.3660 light propagation in tissues 260.5430 polarization 290.1350 backscattering 290.4020 mie theory

Abstract

We report a new method for measuring particle size distribution (PSD) and refractive index of the top layer in a two-layer tissue phantom simulated epithelium tissue by varying the azimuth angle of incident linearly polarized light. The polarization gating technique is used to decouple the single and multiple scattering components in the returned signal. The theoretical model based on Mie theory is presented and a nonlinear inversion method -- floating genetic algorithm -- is applied to inverting the azimuth dependence of component of polarization light backscattered. The experiment results demonstrate that the size distribution and refractive index of the scatters of the top layer can be determined by measuring and analyzing the differential signal of the parallel and perpendicular components from a two-layer tissue phantom. The method implies to detect precancerous changes in human epithelial tissue.

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Yong Deng, Qiang Lu, Qingming Luo. Determining particle size distribution and refractive index in a two-layer tissue phantom by linearly polarized light[J]. Chinese Optics Letters, 2006, 4(1): 0145.

Determining particle size distribution and refractive index in a two-layer tissue phantom by linearly polarized light Download： 670次

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