Journal of Innovative Optical Health Sciences, 2017, 10 (3): 1650050, Published Online: Dec. 27, 2018  

Monte Carlo and phantom study in the brain edema models

Author Affiliations
Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, 29 Yudao Street, Nanjing 210016, P.R. China
Abstract
Because the brain edema has a crucial impact on morbidity and mortality, it is important to develop a noninvasive method to monitor the process of the brain edema effectively. When the brain edema occurs, the optical properties of the brain will change. The goal of this study is to access the feasibility and reliability of using noninvasive near-infrared spectroscopy (NIRS) monitoring method to measure the brain edema. Specifically, three models, including the water content changes in the cerebrospinal fluid (CSF), gray matter and white matter, were explored. Moreover, these models were numerically simulated by the Monte Carlo studies. Then, the phantom experiments were performed to investigate the light intensity which was measured at different detecting radius on the tissue surface. The results indicated that the light intensity correlated well with the conditions of the brain edema and the detecting radius. Briefly, at the detecting radius of 3.0 cm and 4.0 cm, the light intensity has a high response to the change of tissue parameters and optical properties. Thus, it is possible to monitor the brain edema noninvasively by NIRS method and the light intensity is a reliable and simple parameter to assess the brain edema.
References

[1] R. Ahmed, B. Anish , “Medical management of cerebral edema,” Neurosurg. Focus 22, 1–12 (2007).

[2] S. Nag, J. Manias, D. Stewart , “Pathology and new players in the pathogenesis of brain edema,” Acta Neuropathologica 118, 197–217 (2009). Crossref, ISI,

[3] H. Peter, T. Ivan, K. Peter , “Surgery for brain edema,” Neurosurgical Focus 22, 1–9 (2007).

[4] D. Liu, X. Zhang, B. Hu, B. P. Ander , “Src family kinases in brain edema after acute brain injury,” Brain Edema XVI, 185–190 (2016).

[5] G. Jamshid, C. Nancy , “Intracranial–pressure monitoring in traumatic brain injury,” New Eng. J. Med. 368, 1751–1752 (2013). ISI,

[6] U.K. Misra, K. Jayantee, G. Gourav , “Hyperosmolar therapy for raised intracranial pressure,” New Eng. J. Med. 367, 2554–2557 (2012). Crossref, ISI,

[7] L. Mangel, Z. Hanzély, T. Kiss, P. Agoston , “CT densitometry of the brain: A novel method for early detection and assessment of irradiation induced brain edema,” Drug Testing Anal. 7, 544–549 (2015). Crossref, ISI,

[8] Y. Li, J. Wang, M. Li , “Quantification of brain edema and hemorrhage by MRI after experimental traumatic brain injury in rabbits predicts subsequent functional outcome,” Neurol. Sci. 33, 731–740 (2012). Crossref, ISI,

[9] B.S.S Edson, H. Roberto, T. Jacobsen Manoel, DA Almir Ferreira, M. Raul , “Cerebral hemodynamic changes gauged by transcranial Doppler ultrasonography in patients with posttraumatic brain swelling treated by surgical decompression,” J. Neurosurg. 104, 93–100 (2006). Crossref, ISI,

[10] Y. Su, H. Jing, Y. Guo, J. Liu, T. Liu, W. Zhang , “Application of noninvasive monitoring of intracranial pressure with flash visual evoked potential (fvep) in treatment of posttraumatic acute diffuse brain swelling (padbs) without hematoma,” J. Modern Electrophysiol. 3, 1–3 (2015).

[11] L. Lixu, D. Weiwei, J. Xunming, C. Lihua, C. Ling, H. Wei , “A new method of noninvasive brain-edema monitoring in stroke: Cerebral electrical impedance measurement, ” Neurolo. Res. 28, 31–37 (2006). Crossref, ISI,

[12] Y. Liu, Y. Wang, Z. Qian , “Monitoring the reduced scattering coefficient of bone tissues on the trajectory of pedicle screw placement using near-infrared spectroscopy,” J. Biomed. Opt. 19, 117002 (2014). Crossref, ISI,

[13] V. R. Kondepati, H. M. Heise, J. Backhaus , “Recent applications of near-infrared spectroscopy in cancer diagnosis and therapy,” Anal. Bioanal. Chem. 390, 125–139 (2007). Crossref, ISI,

[14] Eri Otsukaa, Hiroyuki Abea, Masaki Aburadaa, Makoto Otsuka , “Nondestructive prediction of the drug content of an aspirin suppository by near-infrared spectroscopy,” Drug Develop. Indust. Pharm. 36, 839–844 (2010). Crossref, ISI,

[15] Z. Qian, Sundar Victor, Y. Gu, Cole Giller, H. Liu , “’Look-Ahead Distance’ of a fiber probe used to assist neurosurgery: Phantom and Monte Carlo study,” Opt. Exp. 11, 1844–1855 (2003). Crossref, ISI,

[16] Izumi Nishidate, Keiichiro Yoshida, Satoko Kawauchi, Shunichi Sato, Manabu Sato , “In vivo estimation of light scattering and absorption properties of rat brain using a single–reflectance fiber probe during cortical spreading depression,” J. Biomed. Opt. 20, 1–13 (2015). Crossref, ISI,

[17] B. Chance, H. Liu, T. Kitai, Y. Zhang , “Effects of solutes on optical properties of biological materials:Models, cells, and tissues,” Anal. Biochemi. 227, 351–362 (1995). Crossref, ISI,

[18] J. Xie, Z. Qian, T. Yang, W. Li, G. Hu , “Near-infrared spectroscopy technique to evaluate the effects of drugs in treating traumatic brain edema,” The 9th Int. Conf. Photonics and Imaging in Biology and Medicine, Nanjing, Jiangsu (2011).

[19] Harold K. Kimelberg , “Current concepts of brain edema,” J. Neurosurg. Publishing Group 83, 1051–1059 (2009). Crossref, ISI,

[20] J. Xie, Z. Qian, T. Yang, W. Li, G. Hu , “Minimally invasive assessment of the effect of mannitol and hypertonic saline therapy on traumatic brain edema using measurements of reduced scattering coefficient ( μ′s)μ′s) ,” Appl. Opt. 49, 5407–5414 (2010). Crossref, ISI,

[21] L. Dai, G. Hua, Z. Qian , “Application of near infrared diffusion spectrum in effect of anhydration solution,” Chin. J. Quantum Electron. 27, 737–742 (2010).

[22] L. Wang, SL. Jacques , “Hybrid model of Monte Carlo simulation diffusion theory for light reflectance by turbid media,” J. Opt. Soc. Am. A 10, 1746–1752 (1993). Crossref,

[23] L. Wang, S.L. Jacques, L. Zheng , “MCML–Monte Carlo modeling of light transport in multi–layered tissues,” Comput. Meth. Prog. Biomed. 47, 131–146 (1995). Crossref, ISI,

[24] S Umeyama, T. Yamada , “Monte Carlo study of global interference cancellation by multidistance measurement of near-infrared spectroscopy,” J. Biomed. Opt. 14, 717–722 (2009). Crossref, ISI,

[25] N. Fravi , “Brain edema,” Therapeutische Umschau Revue Thérapeutique 61, 679–686 (2004). Crossref,

[26] J. Xie, Z. Qian, N. Deng, T. Yang, W. Li, G. Hu , “Monitoring traumatic brain injury by using functional near-infrared spectroscopy,, ” Chin. J. Lasers 38, 104004 (2011).

[27] I. Nishidate, C. Mizushima, K. Yoshida et al., “In vivo estimation of light scattering and absorption properties of rat brain using a single-reflectance fiber probe during cortical spreading depression,” J. Biomedi. Opt. 20, 1–13 (2015). Crossref, ISI,

[28] A. H. Hielscher, H. Liu, B. Chance, FK Tittel, S.L. Jacques , “Time Resolved Photon Emission from Layered Turbid Media,” Appl. Opt. 36, 719–728 (1996). Crossref, ISI,

[29] Fang Lin, H. Ding, Feng Wang, Chang Su , “Multi-layer Monte-Carlo simulation for non-invasive near-infrared measurement on head,” J. Optoelectron. Lasers 10, 1–8 (1999). ISI,

[30] L. He, Y. You, T. Yang et al., “Study on mininvasive monitoring of traumatic brain edema in vivo by near–infrared spectroscopy,” Mod. Medi. J. 36, 221–224 (2008).

[31] H. Wang, J. Lu, Q. Luo et al., “The roles of TNF– αα and IL–8 in the pathogenesis of brain edema induced by LPS in rat,” Chi. J. Immunol. 19, 60–62 (2003).

Yubing Liu, Hongke Wang, Yangyang Liu, Weitao Li, Zhiyu Qian. Monte Carlo and phantom study in the brain edema models[J]. Journal of Innovative Optical Health Sciences, 2017, 10(3): 1650050.

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