双波长视网膜血氧测量系统

为了测量视网膜血氧饱和度，本文设计一种以商业眼底相机为平台的双波长视网膜血氧测量系统。该系统将商业眼底相机输出的视网膜像进行二次成像，同时采集含氧血红蛋白和还原血红蛋白的等吸收波段和非等吸收波段图像。对获取的双波长图像进行图像配准、血管分割、光密度比计算等一系列运算，最终完成视网膜血管血氧饱和度的测量。对健康人眼进行重复性测量，动脉和静脉的血氧饱和度平均值分别是 92.85%和 56.75%，标准差的平均值分别为 2.41%和 3.63%，表明系统的准确性和重复性较好。本系统在获取视网膜结构图像的同时获得视网膜血管功能信息，可以为生命科学相关研究、眼底相关疾病的诊断提供有力工具。

Abstract

In order to measure retinal oxygen saturation, a dual-wavelength retinal oximeter based on commercial fundus camera was designed. The system made the retinal image of the commercial fundus camera second imaging, and simultaneously collected dual-wavelength images that respectively represented the same absorption coefficient wavelength images and the different one of oxygenated hemoglobin and de-oxygenated hemoglobin. The retinal oxygen saturation was finally measured after image registration, vessel segmentation and calculation of optic density ratio of the two images. The means oxygen saturation of artery and venules in health human for repeated measurements were 92.85% and 56.75%, respectively. The mean standard deviation was 2.41% for arterioles and 3.63% for venules.The data demonstrate that the system is reliable and reproducible. The system can obtain retinal structural imaging, which provides a useful tool for research of life sciences and diagnosis of retinal-related diseases.

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先永利, 戴云, 高椿明, 杜睿. 双波长视网膜血氧测量系统[J]. 光电工程, 2016, 43(6): 68. XIAN Yongli, DAI Yun, GAO Chunming, DU Rui. Dual-wavelength Retinal Oximeter[J]. Opto-Electronic Engineering, 2016, 43(6): 68.

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