近红外光谱技术用于无创生化检验研究的进展

丁海泉; 卢启鹏; 彭忠琦; 陈星旦

光谱学与光谱分析, 2010, 30 (8): 2107, 网络出版: 2011-01-26

近红外光谱技术用于无创生化检验研究的进展

Progress in Noninvasive Biochemical Examination by Near Infrared Spectroscopy

论文大纲

丁海泉 ^1,2,*卢启鹏 ¹彭忠琦 ¹陈星旦 ¹

作者单位

¹ 中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室, 吉林长春130033

² 中国科学院研究生院, 北京100049

近红外光谱分析无创生化检验血糖血脂 Near infrared spectroscopy Noninvasive biochemical examination Blood glucose Blood lipids

摘要

２０世纪９０年代初, 近红外光谱技术在人体无创生化检验方面的潜力逐渐获得重视。然而, 人体是一个极其复杂多变的检测对象, 因此虽然各研究小组在实验模拟和离体分析方面取得了一定成果, 但在临床应用上始终没有实质性突破。文章讨论了目前阻碍近红外光谱技术实现临床意义上的人体无创生化检验的关键问题, 即信号微弱、组织背景干扰、血流容积变化问题。将国际上现有的近红外无创生化检验研究工作的思路按照分析方法大致归为两类, 即经典近红外分析法和扣除组织背景干扰分析法。详细介绍了这两类研究思路各自的研究现状, 并认为在现有条件下第二类思路更有希望取得临床可以应用的结果。

Abstract

In the early nineties of last century, great importance had been gradually attached to the potential of near-infrared spectroscopy (NIRS) in the human body noninvasive biochemical examination. However, the human body is extremely complex. Although research teams have made some achievements in experimental simulations and in-vitro analysis, there is still no substantive breakthrough in clinical application now. The present paper discusses the key problems which prevent NIRS from achieving human noninvasive clinical biochemical examination, such as weak signal, the interference of human tissue background and the problem of blood volume change. The thoughts of noninvasive biomedical examination using NIRS are divided into two categories in terms of analytical method, that is classical near-infrared analysis and issue background interference elimination analysis. This paper also introduces in detail the current status of the two categories in the world, and believes that the second category is more promising to be successful in clinical application under the existing conditions.

参考文献

[1] Williams P, Norris K. Second Edition, American Association of Cereal Chemists, Inc., 2001.

[2] DING Hai-quan, LU Qi-peng, PIAO Ren-guan, et al(丁海泉, 卢启鹏, 朴仁官, 等). Optics and Precision Engineering(光学精密工程), 2007, 15(12): 1946.

[3] CAO Pu, PAN Tao, CHEN Xing-dan(曹璞, 潘涛, 陈星旦). Optics and Precision Engineering(光学精密工程), 2007, 15(12): 1952.

[4] ZHANG Jun, CHEN Xing-dan, PIAO Ren-guan, et al(张军, 陈星旦, 朴仁官, 等). Optics and Precision Engineering(光学精密工程), 2008, 16(6): 986.

[5] LU Wan-zhen(陆婉珍). Modem Near Infrared Spectroscopy Analytical Technology(Second Edition)(现代近红外光谱分析技术, 第2版). Beijing: China Petrochemical Press(北京: 中国石化出版社), 2007. 306.

[6] NORRIS K. Edited by Murray I & Cowe I A. UK: Ian Michael Publication, 1992. 596.

[7] Heise H M. Handbook of Vibrational Spectroscopy, Edited by John M. Chalmers. John Wiley&Sons, LTD, 2002. 3280.

[8] Saptari V, Youcef-Toumi K. Applied Optics, 2004, 43(13): 2680.

[9] Chen J, Arnold M A, Small G W. Analytical Chemistry, 2004, 76(18): 5405.

[10] Maruo K, Oota T, Tsurugi M, et al. Applied Spectroscopy, 2006, 60(4): 441.

[11] CHEN Hua-cai, YANG Zhong-guo, CHEN Xing-dan, et al(陈华才, 杨仲国, 陈星旦, 等). Chinese Journal of Analysis Laboratory(分析实验室), 2005, 24(7): 17.

[12] Burmeister J J, Arnold M A. Clinical Chemistry, 1999, 45(9): 1621.

[13] Samann A. Exp. Clin. Endocrinol. Diabetes, 2000, 108: 406.

[14] Maruo K, Oota T, Tsurugi M, et al. Applied Spectroscopy, 2006, 60(12): 1423.

[15] CHEN Wen-liang, CUI Hou-xin, LIU Rong, et al(陈文亮, 崔厚欣, 刘蓉, 等). Journal of Biomedical Engineering(生物医学工程学杂志), 2004, 21(5): 824.

[16] CHEN Wen-liang, YANG Yue, XU Ke-xin, et al(陈文亮, 杨越, 徐可欣, 等). Nanotechnology and Precision Engineering(纳米技术与精密工程), 2007, 5(4): 298.

[17] Hertzman A. Proc. Soc. Exp. Biol. Med., 1937, 37: 529.

[18] Mendelson Y. Clinical Chemistry, 1992, 38(9): 1601.

[19] Jeon K. Journal of Biomedical Optics, 2002, 7(1): 45.

[20] Yamakoshi K, Yamakoshi Y. Journal of Biomedical Optics, 2006, 11(5): 054028.

[21] CHEN Xing-dan(陈星旦). Optics and Precision Engineering(光学精密工程), 2008, 16(5): 759.

[22] LIU Rong, XU Ke-xin, CHEN Wen-liang, et al(刘蓉, 徐可欣, 陈文亮, 等). Science in China Series G: Physics, Mechanics, Astronomy(中国科学G辑: 物理学力学天文学), 2007, 37: 124.

丁海泉, 卢启鹏, 彭忠琦, 陈星旦. 近红外光谱技术用于无创生化检验研究的进展[J]. 光谱学与光谱分析, 2010, 30(8): 2107. DING Hai-quan, LU Qi-peng, PENG Zhong-qi, CHEN Xing-dan. Progress in Noninvasive Biochemical Examination by Near Infrared Spectroscopy[J]. Spectroscopy and Spectral Analysis, 2010, 30(8): 2107.

近红外光谱技术用于无创生化检验研究的进展

关于本站 Cookie 的使用提示

全站搜索

近红外光谱技术用于无创生化检验研究的进展

相关论文

相关资讯

关于本站 Cookie 的使用提示

全站搜索